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I.–J. Wang, T.–H. Chiang, Y.–F. Shih, L. Lin, J.–W. Shieh, T.–H. Wang, P.–T. Hung; The Association of Single Nucleotide Polymorphisms at the MMP9 Genes with Susceptibility to Acute Primary Angle Closure Glaucoma . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5447.
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© ARVO (1962-2015); The Authors (2016-present)
To study the relationships between single nucleotide polymorphisms (SNPs) of extracellular matrix (ECM), matrix metalloproteases (MMPs), tissue inhibitors of MMPs (TIMPs), and other glaucoma–associated genes and primary acute primary angle closure glaucoma (PACG).
We extracted DNA samples from 47 adult patients with acute PACG and 46 controls subjects to study the relationships between these genes and acute PACG. Genotyping was performed at 35 genes by the GenomeLab SNPstream genotyping system after PCR amplification of chromosomal DNA. The association between these genetic polymorphisms and risk of primary PACG was estimated by Χ2 and logistic regression.
The genotyping success rate was 99%. The genotyping for the MMP9 (rs2664538) was significantly different between the two groups (p=0.00005) and the odd ratio was 6.20 (95% CI: 2.52–15.223, p<0.00001). However, there were no associations of SNPs of other genes with acute PACG.
Our results reveal that SNP (rs2664538) which is located at the MMP9 gene may be associated with acute PACG.
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