Purchase this article with an account.
J. Oh, I.–K. Oh, J. Song, B. No, Y.–S. Jung, H.–M. Kim, K. Huh; The Effect of Temporal Exposure With Triamcinolone Acetonide on the Cultured Fibroblast of Rat and Human RPE Cell . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5536.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of temporal exposure with triamcinolone acetonide on the cell viability of cultured choroidal fibroblast and retinal pigment epithelial cells
After administration of various concentrations (0.01 mg/ml or 1 mg/ml) and exposure time (5 minute, 15 minute, 30 minute, continued exposure) of triamcinolone acetonide on cultured fibroblast and RPE cells, we evaluated cell viability at 1, 3, 5days and compared with mitomycin (0.01 ug/ml or 1 ug/ml).
Triamcinolone acetonide administration resulted in decrease in fibroblast and RPE cell proliferation. The proliferation of the cultured both cells were significantly inhibited by triamcinolone acetonide even if in low dose and shot exposure time.
Triamcinolone acetonide, even if used very temporarily with low dose during vitrectomy, may help inhibiting postoperative proliferative vitreoretinopathy by fibroblast or RPE cell. However, because it is not non–toxic to RPE cell, it has to be used carefully in staining of ILM in Macular hole surgery.
This PDF is available to Subscribers Only