May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Microstructural Abnormalities in MEWDS Demonstrated by Ultrahigh Resolution Optical Coherence Tomography
Author Affiliations & Notes
  • M. Nguyen
    New England Eye Center, Tufts–New England Medical Center, Boston, MA
  • A.J. Witkin
    New England Eye Center, Tufts–New England Medical Center, Boston, MA
  • E. Reichel
    New England Eye Center, Tufts–New England Medical Center, Boston, MA
  • T.H. Ko
    Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • J.G. Fujimoto
    Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • J.S. Schuman
    UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • J.S. Duker
    New England Eye Center, Tufts–New England Medical Center, Boston, MA
  • Footnotes
    Commercial Relationships  M. Nguyen, None; A.J. Witkin, None; E. Reichel, None; T.H. Ko, None; J.G. Fujimoto, None; J.S. Schuman, None; J.S. Duker, None.
  • Footnotes
    Support  NIH Grant R01–EY11289–16, R01–EY013178–06, P30–EY008098, P30–EY13078
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 5653. doi:
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      M. Nguyen, A.J. Witkin, E. Reichel, T.H. Ko, J.G. Fujimoto, J.S. Schuman, J.S. Duker; Microstructural Abnormalities in MEWDS Demonstrated by Ultrahigh Resolution Optical Coherence Tomography . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5653.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Histopathological studies of acute multiple evanescent white dot syndrome (MEWDS) have not been reported because of the transient and benign nature of the disease. Ultrahigh resolution optical coherence tomography (UHR–OCT), capable of high resolution in vivo imaging, offers a unique opportunity to visualize retinal microstructure in the disease.

Methods: : UHR–OCT images of the maculas of five patients with MEWDS were obtained and analyzed. Diagnosis was based on clinical presentation, examination, visual field testing, and angiography.

Results: : UHR–OCT revealed disturbances in the junction between the inner and outer photoreceptor segments (IS/OS) in each of the five patients (six eyes) with MEWDS. In addition, thinning of the outer nuclear layer was seen in the case of recurrent MEWDS, suggesting that repeated episodes of MEWDS may result in photoreceptor atrophy.

Conclusions: : Subtle disruptions of the photoreceptor IS/OS junction are demonstrated in all eyes affected by MEWDS. UHR–OCT may be a useful adjunct to diagnosis and monitoring of MEWDS.

Keywords: chorioretinitis • imaging/image analysis: clinical • photoreceptors 
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