May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Alternative Measures of Fluorescein Leakage in the Angiographic Evaluation of Eyes With AMD: Experience of the Wisconsin Reading Center and the V.I.S.I.O.N. Trials
Author Affiliations & Notes
  • J.A. Elledge
    Ophthalmology, University of Wisconsin, Madison, WI
  • M.K. W. Webster
    Ophthalmology, University of Wisconsin, Madison, WI
  • M. Altaweel
    Ophthalmology, University of Wisconsin, Madison, WI
  • M. Goldbaum
    (OSI) Eyetech Pharmaceuticals, New York, NY
  • E.T. Cunningham
    (OSI) Eyetech Pharmaceuticals, New York, NY
  • M.D. Davis
    Ophthalmology, University of Wisconsin, Madison, WI
  • B. Katz
    (OSI) Eyetech Pharmaceuticals, New York, NY
  • Footnotes
    Commercial Relationships  J.A. Elledge, None; M.K.W. Webster, None; M. Altaweel, None; M. Goldbaum, (OSI) Eyetech Pharmaceuticals, E; E.T. Cunningham, (OSI) Eyetech Pharmaceuticals, E; M.D. Davis, None; B. Katz, (OSI) Eyetech Pharmaceuticals, E.
  • Footnotes
    Support  Eyetech Pharmaceuticals
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 5692. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J.A. Elledge, M.K. W. Webster, M. Altaweel, M. Goldbaum, E.T. Cunningham, M.D. Davis, B. Katz; Alternative Measures of Fluorescein Leakage in the Angiographic Evaluation of Eyes With AMD: Experience of the Wisconsin Reading Center and the V.I.S.I.O.N. Trials . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5692.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

To compare alternative methods of assessing fluoresceinleakage in eyes with neovascular Age–Related Macular Degeneration.

 
Methods:
 

565 participants in the 2 V.I.S.I.O.N. trials comparingusual care (n=276) and 0.3mg Pegaptanib Sodium (Macugen®)(n=280) were evaluated at baseline and week 54. Leakage in thefluorescein angiogram was documented using 2 methods: a) the2– dimensional area of leakage was determined in discareas at each visit, and b) baseline and week 54 images weredirectly compared to allow a global estimate of change in leakage(a combination of area and intensity) from baseline: substantially,definitely or questionably less leakage; leakage the same; orquestionably, definitely, or substantially more leakage. Graderswere masked to treatment group and to gradings by the alternativemethod.

 
Results:
 

*average diameter of leakage area in disc diameters (DD)  

 

 
Conclusions:
 

The global comparison, which takes into accountintensity as well as area of leakage, supports the findingsof direct measurement of leakage area. Both methods supportthe primary visual outcome of the trials. The global assessmentmethod correlates more highly with the visual acuity endpointwith a statistically significant benefit for the 0.3mg groupvs. sham at the primary endpoint, and is more intuitively obviousto clinicians. This method will be incorportated into futureclinical trials evaluating exudative AMD to supplement our abilityto evaluate lesion activity and correlate morphologic and visualacuity endpoints.

 
Keywords: age-related macular degeneration • choroid: neovascularization • clinical research methodology 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×