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F. Boscia, C. Furino, N. Cardascia, L. Sborgia, T. Micelli Ferrari, C. Sborgia; Fundus Autofluorescence And Optical Coherence Tomography Morphologic Data Of Adult Vitelliform Macular Dystrophy . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5694. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To report macular autofluorescence (AF) and optical coherence tomography (OCT 3) morphologic data of adult vitelliform macular dystrophy (AVMD)
Twenty eyes of fifteen consecutive patients with AVMD were retrospectively evaluated. Five had a bilateral macular involvement. ETDRS best correct visual acuity (BCVA), retinal pigment epithelium AF measured by confocal Scanning Laser Ophthalmoscope and macular third–generation optical coherence tomography were evaluated.
BCVA ranged between 1.2 and 0.1. Autofluorescence findings showed increased fluorescence within the foveal yellow lesion in 18 eyes (90%); two (11.1%) of these showed an additional small area of reduced AF; in two eyes (10%) a reduced level of AF compared to background signal was revealed. OCT 3 showed area of hyperreflectivity between RPE layer and the photoreceptors layer, compatible in size with the area of increased AF in 18 eyes (90%); three (16.6%) of these had a reduced thickness of the neurosensory retina over the lesion and two (11.1%) had a well–defined serous retinal detachment around the hyperreflective area.
AF and OCT 3 are useful for confirming the diagnosis of AVMD and to follow up these patients, better understanding fundus ophthalmoscopy and fluorescein angiography pattern. Autofluorescence indicates lipofuscin–like material accumulation findings in eyes with AVMD; OCT 3, because of its high resolution, shows this material located between the elevated photoreceptors layer and the retinal pigment epithelium.
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