May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Tachyphylaxis of Triamcinolone Acetonide Effectiveness After Multiple Injections
Author Affiliations & Notes
  • J.O. Mason
    Ophthalmology, Retina Consultants of Alabama, Birmingham, AL
  • A.V. Talalight
    Ophthalmology, Retina Consultants of Alabama, Birmingham, AL
  • T.L. Emond
    Ophthalmology, Retina Consultants of Alabama, Birmingham, AL
  • R.M. Feist
    Ophthalmology, Retina Consultants of Alabama, Birmingham, AL
  • M.F. White, Jr
    Ophthalmology, Retina Consultants of Alabama, Birmingham, AL
  • M.L. Thomley
    Ophthalmology, Retina Consultants of Alabama, Birmingham, AL
  • B.W. Roberts
    Ophthalmology, Retina Consultants of Alabama, Birmingham, AL
  • P.A. Nixon
    Ophthalmology, Retina Consultants of Alabama, Birmingham, AL
  • G. McGwin, Jr
    Ophthalmology, Retina Consultants of Alabama, Birmingham, AL
  • Footnotes
    Commercial Relationships  J.O. Mason, None; A.V. Talalight, None; T.L. Emond, None; R.M. Feist, None; M.F. White, Jr., None; M.L. Thomley, None; B.W. Roberts, None; P.A. Nixon, None; G. McGwin, Jr., None.
  • Footnotes
    Support  Research to Prevent Blindness; New York, New York
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 283. doi:
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      J.O. Mason, A.V. Talalight, T.L. Emond, R.M. Feist, M.F. White, Jr, M.L. Thomley, B.W. Roberts, P.A. Nixon, G. McGwin, Jr; Tachyphylaxis of Triamcinolone Acetonide Effectiveness After Multiple Injections . Invest. Ophthalmol. Vis. Sci. 2005;46(13):283.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To evaluate the possible tachyphylactic reduction of the effectiveness of triamcinolone acetonide for branch retinal vein occlusion (BRVO) after multiple intravitreal injections. Methods: Retrospective medical record review of patients receiving serial intravitreal injections of 4mg triamcinolone acetonide in a private vitreoretinal practice. Inclusion criteria included a diagnosis of BRVO of <12 months duration, best corrected visual acuity (BCVA) of <20/50, and no prior treatment for BRVO. Patients were excluded if they had any concurrent retinal disease, extensive macular hemorrhage, retinal neovascularization or uncontrolled glaucoma. Minimum follow up was 6 months (mean 13 months). Results: Mean pre–injection BCVA was 20/150. One month after injection #1, #2, and #3, mean BCVA was 20/50, 20/70, and 20/80, respectively. The greatest improvement in BCVA occurred after injection #1 (78% of patients). Best improvement in BCVA after injection #2 and #3 was 22% and 0%, respectively. The greatest reduction in central retinal thickness (CRT) on ocular coherence tomography (OCT) also occurred after injection #1, in 67% of patients (after injection #2 in 22% and after injection #3 in 11%). Conclusions: In this series of patients, the greatest beneficial effect of intravitreal triamcinolone acetonide (IVTA) on reducing CRT and improving BCVA occurred after the first injection. Although IVTA was less effective after a second injection, and least effective after a third injection, 67% of patients had improved vision and 83% had decreased CRT after a third IVTA injection.

Keywords: vascular occlusion/vascular occlusive disease • retina • pharmacology 
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