May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Dye–Enhanced Photocoagulation (DEP) for Treatment of Choroidal Neovascularization in Age–Related Macular Degeneration: Interim, Preliminary Data From an On–Going Study
Author Affiliations & Notes
  • G. Levi
    Department of Ophthalmology, University of Brescia, Brescia, Italy
  • P. Danzi
    Department of Ophthalmology, University of Brescia, Brescia, Italy
  • C. Veronese
    Department of Ophthalmology, University of Brescia, Brescia, Italy
  • R. Flower
    Department of Ophthalmology, University of Maryland, Baltimore, MD
    Department of Ophthalmology, New York University, New York, NY
  • G. Staurenghi
    Department of Ophthalmology, University of Brescia, Brescia, Italy
    Department of Ophthalmology, University of Milan, Milan, Italy
  • Footnotes
    Commercial Relationships  G. Levi, None; P. Danzi, None; C. Veronese, None; R. Flower, Novadaq Technologies C; G. Staurenghi, Novadaq Technologies C; Heidelberg Engineering R.
  • Footnotes
    Support  Novadaq Technologies
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 292. doi:
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      G. Levi, P. Danzi, C. Veronese, R. Flower, G. Staurenghi; Dye–Enhanced Photocoagulation (DEP) for Treatment of Choroidal Neovascularization in Age–Related Macular Degeneration: Interim, Preliminary Data From an On–Going Study . Invest. Ophthalmol. Vis. Sci. 2005;46(13):292.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To compare efficacy of choroidal neovascular membrane (CNV) feeder vessel treatment (FVT) preformed by application of 810 nm laser energy during indocyanine green (ICG) dye transit through the feeder vessels (i.e., DEP) to application of the laser energy alone. Methods: A fundus camera was modified for ICG angiography by replacing its xenon flash lamp with an 810 nm wavelength diode laser. Live ICG images were acquired by a CCD video camera and displayed on a LCD monitor located above the patient’s eye. The output fiber optic of an 810 nm laser photocoagulator was mounted on a joystick–controlled micromanipulator in the fundus camera’s optical system for positioning the photocoagulator laser beam on the fundus while viewing live ICG video images of the choroidal vasculature. The device makes possible precise delivery of photocoagulation energy to CNV FVs upon arrival of a secondarily–injected, high–concentration ICG dye bolus in a targeted FV. Patients are randomized to ICG–DEP FVT or FVT alone. Results: 24 patients randomized to date (12 FVT / 12 ICG–DEP FVT). Data at 6 months are consistent with published outcomes for overall FVT vessel closure, but there were differences related to the FVT method applied: 83% closed in the ICG–DEP FVT arm, 64% closed in the FVT only arm. The number of laser burns to achieve the closure with DEP FVT were less than FVT (3 to 9 vs. 100 to 300). Conclusions: Preliminary data analysis suggests that feeder vessels are identifiable and treatable during the dye transit. ICG–DEP appears to facilitate FVT by reducing the number of burns necessary for vessel closure and makes the treatment of larger diameter new vessels possible.

Keywords: age-related macular degeneration • clinical (human) or epidemiologic studies: systems/equipment/techniques • choroid: neovascularization 
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