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A. Oliver, T.A. Ciulla, R. Maturi; Comparison of Photodynamic Therapy, Intravitreal Triamcinolone or a Combined Regimen as Initial Treatment of Choroidal Neovascularization . Invest. Ophthalmol. Vis. Sci. 2005;46(13):317.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Intravitreal tramcinolone (IVT) may have a role in the treatment of exudative age–related macular degeneration (AMD), either as monotherapy or synergistic combination therapy with photodynamic therapy (PDT). The present study compares the outcomes of individuals with CNV treated with PDT, IVT, or both at the time of initial presentation. Methods: Outcomes of all patients referred for AMD treatment between January and October 2004, and whose initial treatment included IVT injection, were analyzed. Outcomes were measured as change in visual acuity (VA) expressed in snellen lines, recorded 3 months after first treatment. Statistical Analysis was performed using the Kruskal–Wallis test. Results: 32 new patients were identified as initially treated with IVT. The individuals were further divided into 2 groups: 22 treated with simultaneous PDT/IVT and 10 treated with triamcinolone only; additional 19 base line VA–matched controls (p=0.3) treated only with PDT were included. Statistical analysis showed a significant difference between the three groups (p=0.01; mean change xPDT=–1.31, xIVT=–0.1, xPDT/IVT=0.27). Further analysis showed no difference between the two IVT–treated groups (p=0.47), but they both exhibited better visual acuity when compared to the PDT–only treatment group (p=0.055 and p<0.005 for IVT and IVT/PDT groups respectively). Conclusions: In this short term study, IVT is associated with a favorable visual acuity trend as compared to standard PDT only, either when applied in combination with PDT or as single agent. Further study is warranted.
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