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H. Kagokawa, A. Takahashi, A. Takamiya, F. Mori, Y. Minami, Y. Kato, R. Kinouchi, S. Ishiko, A. Yoshida; Changes in Choroidal Blood Flow After Photodynamic Therapy in Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2005;46(13):334.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: We reported previously that pulsatile ocular blood flow (POBF), a parameter for evaluating choroidal blood flow, was lower in patients with exudative age–related macular degeneration (AMD) than in normal subjects (BJO. 2001; 85:531–533). The aim of this study is to evaluate the changes in choroidal blood flow after photodynamic therapy (PDT) in patients with exudative AMD. Methods: Eight patients with exudative AMD (8 eyes; 6 men, 2 women; age range, 63–78 years) who underwent PDT were included. PDT with verteporfin (Visudyne®) was administered. We examined fluorescein angiography (FA), indocyanine green angiography (IA), and POBF using Langham OBF computerized tonometry before and 10 days after administration of PDT. Results: The POBF 10 days after PDT (median, 578 µl/min) increased significantly compared to before PDT (median, 487 µl/min) (p< 0.05). Early–phase FA, and IA showed low fluorescence corresponding to the area of laser irradiation in the eye. There was no filling delay of the dye in the large choroidal vessels on IA. Conclusions: The results of this study for the first time suggested that the choroidal blood flow may increase 10 days after PDT. It is possible that the choroidal blood flow increase compensates for the occluded choriocapillaris in the area of laser irradiation.
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