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M. Parrochia, P. Covarrubias, H. Quiroz–Mercado, J. Jimenez; The Effect of Lisinopril Treatment in ERG Oscillatory Potentials Amplitude in Normotensive Diabetic Type 2 Patients . Invest. Ophthalmol. Vis. Sci. 2005;46(13):349.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To investigate the effect of Lisinopril therapy on ERG oscillatory potential in normotensive diabetics patients without retinopathy. Methods: We recruited normotensive diabetic patients without retinopathy with less than 5 years of disease. Adults with an average of 45 years old. All patients underwent full physical examination including BP, 24 hours urine analysis, glycosilate hemoglobine, HB, and fundus photographs. ERG oscillatory potentials were done before and after3 months of the beginning of treatment with oral Lisinopril 10 mg. Results: We have seen an oscillatory potentials amplitude normalization tendency in each 4 waves of each oscillatory potential between pre–treatment and 3 month post–treatment exams. Average values for OD and OS for each wave at 3 month control was: In OD wave nº1 improved 0.62 uv, wave nº2 improved 0.03 uv, wave nº3 improved 2.6 uv, and wave nº4 decreased 1.69 uv . In OS wave nº1 improved 1.14, wave nº2 improved 4.34 uv, wave nº3 improved 2.64 uv, and wave nº4 decreased 0.64 uv. Conclusions: The study showed that Lisinopril therapy produced improvement in oscillatory potentials amplitude in normotensive tipe II diabetics.
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