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D.N. Colombero, D.E. Pelayes, J. Zarate, C.H. Pastore; Organ–Specific Intravascular Coagulation in Diabetic Neovascular Glaucoma . Invest. Ophthalmol. Vis. Sci. 2005;46(13):352.
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Purpose: an organ–specific process has been implicated in the genesis of diabetes in different organs, but not yet in the chamber angle. The aim of this study was to determine the presence of organ–specific intravascular coagulation in diabetic related neovascular glaucoma. Methods: an iridocyclotrabeculectomy was done in patients with diabetic neovascular glaucoma, no light perception vision and ocular pain. The technique includes iris, trabeculum and ciliary body head extraction. The specimens were studied with hematoxilin–eosin, PAS, Masson trichrome and immunohistochemistry. Results: histopathologic study confirmed the presence of organ–specific intravascular coagulation in the chamber angle. That process increases ischemia due to reduction in oxygen supply. Conclusions: an association between organ–specific intravascular coagulation and chamber angle damage in diabetic patients was noted, and its importance in the progression of neovascularization. The clotting cascade alterations due to endothelial and other factors are proposed as responsible for this phenomenon.
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