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K. Kuniyoshi, A. Nakao, N. Uno, Y. Shimomura; Oscillatory Potentials Recorded During Dark Adaptation on Patients With Diabetes Mellitus . Invest. Ophthalmol. Vis. Sci. 2005;46(13):374.
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Purpose: To evaluate oscillatory potentials recorded during dark adaptation on patients with diabetes mellitus (DM). Methods: Flash electroretinogram (ERG) was recorded on eyes with DM (age 58±10 y. o.) and normal 12 eyes (age 63±7 y. o.). Eyes with DM were divided into four groups according to degree of diabetic retinopathy (DR) : (1) NDR group (15 eyes, age 61±17 y. o.): no DR was seen, (2) SDR group (11 eyes, age 56±8 y. o.): simple DR, (3) PPDR group (23 eyes, age 61±6 y. o.): pre–proliferative DR, (4) PDR group (8 eyes, age 53±12 y. o.): proliferative DR. Light adaptation with background light of 80 cd/m2 was performed before examination. Subsequently, flash ERG was recorded nine times at various points during dark adaptation, namely, 0, 1, 3, 5, 7, 10, 15, 20, and 30 minutes after starting dark adaptation. Implicit time of the first, second, third and forth oscsillatory potentials (O1, O2, O3 and O4) was measured and evaluated. Results: O1 was significantly delayed in all DR groups. O2 was delayed in all DR groups for the 5 ERGs recorded up to 7–minute dark adaptation. However, after 10–minute dark adaptation, no significant difference in implicit time was seen among all DR groups and normal eyes. O3 and O4 were delayed in almost all DR groups. In normal eyes, implicit time of O2 was delayed with the progress of dark adaptation. In DR groups, no significant change was seen in implicit time of O2 during dark adaptation. Conclusions: Implicit time of O1 and O2 shown in flash ERG from light adapted eye was most useful for diagnosing the degree of DR. O2 recorded after dark adaptation in eyes with diabetes may have different origin from O2 in normal eyes.
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