Magnetic Resonance Imaging of Dexamethasone treatment on the Increased Blood–Aqueous Barrier of Triolein Emulsion in Cats

Abstract

Abstract: : Purpose: To determine the effect of dexamethasone on the increased permeability of the BAB induced by intra–arterial infusion of triolein emulsion in cats. Methods: An emulsion of 0.1mL triolein in 20mL of saline was infused into the internal carotid artery of cats. Pre– and postcontrast MR images were obtained 30 minutes and 3 hours after embolization. 10 mg/kg of dexamethasone (treatment group, n = 10) or 20 mL of saline (control group, n = 10) was infused right after 30 minutes MR imaging. For the quantitative analysis between the control and treatment groups, the contrast–enhancement ratio (CER = [signal intensity on postcontrast – signal intensity on precontrast]/signal intensity on precontrast) of the anterior and posterior chamber was measured. Statistical analysis was performed using mixed linear model. Results: Mean CERs (anterior/posterior chamber) were 0.018/0.024 at 30 minutes and 0.987/0.470 at 3 hours in the treatment group, and 0.014/0.048 at 30 minutes and 1.143/1.084 at 3 hours in the control group. Mean CERs showed no difference between the groups in the anterior or posterior chambers at 30 minutes and in the anterior chamber at 3 hours. However, at 3 hours, mean CER in the posterior chamber was significantly lower in the treatment group than that in the control group (p = 0.008). Conclusions: Dexamethasone could block the effect of triolein emulsion to increase permeability of BAB in cats.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • inflow/ciliary body