May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Helical Intravitreal Triamcinolone Implant : Surgical Method Development and Outcomes
R. Tano; P.A. A. Mello–Filho; D. Guven; T. Ratanapakorn; N.R. F. Beeley; E. de Juan, Jr; S.E. Varner
Author Affiliations & Notes
  • R. Tano
    Ophthalmology, Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • P.A. A. Mello–Filho
    Ophthalmology, Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • D. Guven
    Ophthalmology, Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • T. Ratanapakorn
    Ophthalmology, Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • N.R. F. Beeley
    Ophthalmology, Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • E. de Juan, Jr
    Ophthalmology, Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • S.E. Varner
    Ophthalmology, Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • Footnotes
    Commercial Relationships  R. Tano, None; P.A.A. Mello–Filho, None; D. Guven, None; T. Ratanapakorn, None; N.R.F. Beeley, None; E. de Juan, Jr., InnoRx, Inc. I, P; S.E. Varner, InnoRx, Inc. P.
  • Footnotes
    Support  NIH Grant EY03040, Fletcher Jones Foundation
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 483. doi:
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      R. Tano, P.A. A. Mello–Filho, D. Guven, T. Ratanapakorn, N.R. F. Beeley, E. de Juan, Jr, S.E. Varner; Helical Intravitreal Triamcinolone Implant : Surgical Method Development and Outcomes . Invest. Ophthalmol. Vis. Sci. 2005;46(13):483.

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Abstract

Abstract: : Purpose: To investigate outcomes of a surgical method for implanting a helical intravitreal implant. Methods: Sustained release implants containing 925 mcg of triamcinolone acetonide were placed in 112 eyes of 82 rabbits and followed clinically for up to 6 mos (6 mos (15 eyes), 3 mos (73 eyes), 6 wks (12 eyes), 4 wks (10 eyes), and 1 wk (2 eyes)). The implant was positioned intravitreally by insertion through the sclera, 3 mm from the limbus, following a 3–mm conjunctival and Tenon dissection in the superotemporal quadrant. Full– or half–thickness sclerotomies were performed with a 30 g needle before implantation. The implant was rotated through the sclerotomy using a custom surgical instrument. Once the implant cap firmly abutted the sclera, the conjunctiva was closed with 1 or 2 absorbable sutures. To assess clinical complications of implantation, macroscopic superficial findings and indirect ophthalmoscopic examination were performed, and IOP was measured, pre– and postoperatively. Results: The entire implantation procedure consistently took 15–20 min. No extrusion or migration of the implants were observed in up to 6 mos of follow–up. At 6 mos, focal superotemporal cataracts were observed in 10 of 15 eyes (67%): these were attributed to contact between the relatively large and posterior rabbit lens and the implant tip. Pigmented debris on the tip of coil was observed in 15 eyes (13%) immediately after the procedure. Mild vitreous hemorrhage was observed in 31 eyes (28%) immediately postop, but it did not interfer with fundus visualization. IOP was stable between baseline and 1 wk postop. No differences were seen between the full– and half–thickness sclerotomy groups. One case of infectious endophthalmitis was seen at 17 days (0.89% incidence). No retinal hemorrhage, tears, or detachment were seen during this study. Conclusions: The helical implant was safely inserted using custom surgical instruments. The 15–20 min procedure was relatively straightforward. Other than 1 case of endophthalmitis, no surgical complications were observed.

Keywords: corticosteroids • vitreoretinal surgery • vitreous 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2015 Association for Research in Vision and Ophthalmology.
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