May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Helical Intravitreal Triamcinolone Implant: An Explantation Survival Study
T. Ratanapakorn; P.A. A. Mello–Filho; R. Tano; N.R. F. Beeley; D. Guven; J. Wang; M. La Fontaine; E. de Juan, Jr; S.E. Varner
Author Affiliations & Notes
  • T. Ratanapakorn
    Department of Ophthalmology, Keck School of Medicine at USC, Doheny Retina Institute, Doheny Eye Institute, Los Angeles, CA
  • P.A. A. Mello–Filho
    Department of Ophthalmology, Keck School of Medicine at USC, Doheny Retina Institute, Doheny Eye Institute, Los Angeles, CA
  • R. Tano
    Department of Ophthalmology, Keck School of Medicine at USC, Doheny Retina Institute, Doheny Eye Institute, Los Angeles, CA
  • N.R. F. Beeley
    Department of Ophthalmology, Keck School of Medicine at USC, Doheny Retina Institute, Doheny Eye Institute, Los Angeles, CA
  • D. Guven
    Department of Ophthalmology, Keck School of Medicine at USC, Doheny Retina Institute, Doheny Eye Institute, Los Angeles, CA
  • J. Wang
    Department of Ophthalmology, Keck School of Medicine at USC, Doheny Retina Institute, Doheny Eye Institute, Los Angeles, CA
  • M. La Fontaine
    Department of Ophthalmology, Keck School of Medicine at USC, Doheny Retina Institute, Doheny Eye Institute, Los Angeles, CA
  • E. de Juan, Jr
    Department of Ophthalmology, Keck School of Medicine at USC, Doheny Retina Institute, Doheny Eye Institute, Los Angeles, CA
  • S.E. Varner
    Department of Ophthalmology, Keck School of Medicine at USC, Doheny Retina Institute, Doheny Eye Institute, Los Angeles, CA
  • Footnotes
    Commercial Relationships  T. Ratanapakorn, None; P.A.A. Mello–Filho, None; R. Tano, None; N.R.F. Beeley, None; D. Guven, None; J. Wang, None; M. La Fontaine, None; E. de Juan Jr., InnoRx, Inc. I, P; S.E. Varner, InnoRx, Inc. P.
  • Footnotes
    Support  NIH EY03040, Fletcher Jones Foundation
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 484. doi:
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      T. Ratanapakorn, P.A. A. Mello–Filho, R. Tano, N.R. F. Beeley, D. Guven, J. Wang, M. La Fontaine, E. de Juan, Jr, S.E. Varner; Helical Intravitreal Triamcinolone Implant: An Explantation Survival Study . Invest. Ophthalmol. Vis. Sci. 2005;46(13):484.

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Abstract

Abstract: : Purpose: To evaluate outcomes of an explantation procedure for the helical intravitreal implant in rabbit eye. Methods: Thirteen rabbits received a helical intravitreal drug delivery implant OD. Eleven rabbits were followed for 6 weeks and 2 were followed for 6 months after implant. The implants were then removed and rabbits were followed clinically for 6 weeks. For explantation, a small conjunctival incision was made over the implant cap; the implant was grasped with surgical forceps or a custom surgical instrument and upward pressure was applied. Two wound closure techniques were used: 6 eyes were closed with a single scleral suture, while the scleral wound was left open in the remaining 7 eyes. All eyes received a conjunctival suture. Ocular examination, fundus photography, and ERG were performed before and after explantation. At the conclusion of the study, the globes were prepared for histologic study. Results: IOP and ERG after explantation were comparable between the 2 groups. Complete conjunctival healing was observed after both wound closure techniques. After explantation, vitreous hemorrhage was found in 6 rabbits, 2/6 (33.33%) from scleral sutured group and 4/7 (57.14%) from non–sutured group. In 2 rabbits of the non–sutured group, the vitreous hemorrhage obscured the view of the fundus. IOP dropped slightly post explantation in both groups. Average IOP before and 1 week after explantation were 17.33 and 13.61 mmHg in sutured group and 15.71 and 12.90 mmHg in non–sutured group, respectively. There were no signs of endophthalmitis, other infection or retinal detachment in the operated eyes. Preliminary histologic study showed established scleral wound healing in both groups by 6 weeks. Conclusions: Both wound closure techniques prevented infection and resulted in wound healing. In no case did implant removal result in retinal detachment. Immediate hypotony resulting from the removal of an implanted device may contribute to post operative vitreous hemorrhage. Suturing the wound with a single suture may reduce the rate of hemorrhage.

Keywords: corticosteroids • vitreoretinal surgery • vitreous 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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