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A.M. Fea, G. Restagno, A. Fornero, F. Lombardo, C. de Leo, T. Rolle, B. Brogliatti, F.M. Grignolo; The Role of APOE and SOD 1 Polymorfisms in Primary Open–Angle Glaucoma . Invest. Ophthalmol. Vis. Sci. 2005;46(13):50.
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Primary open–angle glaucoma (POAG) is likely to be a genetically heterogeneous disorder that results from the interaction of multiple genes and environmental factors. Oxidative stress might play a role in the etiology of POAG. We tested the hypothesis that genetic polymorphism of the APOE and of the SOD 1 gene are associated with POAG
73 POAG patients (age: 62,64+/–12,09 y; 40f; 33m) with a minimum follow–up of 7 years and a IOP during follow–up never exceeding 19 mm Hg(G) were included in the study. During the follow–up visual fields were performed at least yearly. 20 patients showed a progression as assessed by AGIS during the follow–up. After digesting DNA with restriction enzymes, PCR was performed to test for APOE and SOD1 gene polymorfisms. Allelic frequencies were compared to 100 age and sex–matched subjects No significant differences between POAG and controls were evident for both the APOE (chi=0.72)and the SOD1 (chi=0.04) genotypes. The allelic distribution was similar in the progressing and the non progressing groups (tab.1)..
APOE and SOD1 do not appear to be contributory to POAG
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