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M. Fossarello, M.S. Galantuomo, C. Malloci, G. Cappai, M. Carta, V. Serra, J. Loudianos, E. Peiretti, I. Zucca; Analysis of Fundus Autofluorescence in Patients With Different Genotypes and Phenotypes of Retinitis Pigmentosa (RP) . Invest. Ophthalmol. Vis. Sci. 2005;46(13):520.
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to investigate the pattern of fundus autofluorescence and the correlation with the genotypes in a population of 410 patients affected by different types of RP.
Patients selected from our RP database, including 410 subjects with different types of RP, autosomal dominant, autosomal recessive, sporadic, mitochondrial and sindromic, were examined for analysis of the pattern of fundus autofluorescence (SLO–HRA Heidelberg). Ophthalmologic examination included refraction, best visual acuity at distance, slit lamp examination, fundoscopy, fundus photography, computerized perimetry (Humphrey), microperimetry (Nidek) color vision (Lanthony Panel D 15 test) dark adaptometry (Goldmann–Weekers) and electroretinography.
. All patients under examination showed a variably sized parafoveal ring of autofluorescence together with visual function and fundus changes typical of RP. In a number of cases a "negative" ring, with absence of autofluorescence, was observed. The size of autofluorescence ring is correlated with the size of residual central visual field, but not with the age of patients. The pattern of autofluorescence was not correlated with the genotype.
A parafoveal ring of autofluorescence may represent a reliable diagnostic clinical parameter in RP, predicting the extent of photoreceptor degeneration in the the macular area.
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