May 2005
Volume 46, Issue 13
ARVO Annual Meeting Abstract  |   May 2005
Analysis of Fundus Autofluorescence in Patients With Different Genotypes and Phenotypes of Retinitis Pigmentosa (RP)
Author Affiliations & Notes
  • M. Fossarello
    Ophthalmology, University, Cagliari, Italy
  • M.S. Galantuomo
    Ophthalmology, University, Cagliari, Italy
  • C. Malloci
    Ophthalmology, University, Cagliari, Italy
  • G. Cappai
    Ophthalmology, University, Cagliari, Italy
  • M. Carta
    Ophthalmology, University, Cagliari, Italy
  • V. Serra
    Ophthalmology, University, Cagliari, Italy
  • J. Loudianos
    Ospedale Regionale Microcitemie, ASL 8, Cagliari, Italy
  • E. Peiretti
    Ophthalmology, University, Cagliari, Italy
  • I. Zucca
    Ophthalmology, University, Cagliari, Italy
  • Footnotes
    Commercial Relationships  M. Fossarello, None; M.S. Galantuomo, None; C. Malloci, None; G. Cappai, None; M. Carta, None; V. Serra, None; J. Loudianos, None; E. Peiretti, None; I. Zucca, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 520. doi:
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      M. Fossarello, M.S. Galantuomo, C. Malloci, G. Cappai, M. Carta, V. Serra, J. Loudianos, E. Peiretti, I. Zucca; Analysis of Fundus Autofluorescence in Patients With Different Genotypes and Phenotypes of Retinitis Pigmentosa (RP) . Invest. Ophthalmol. Vis. Sci. 2005;46(13):520.

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      © ARVO (1962-2015); The Authors (2016-present)

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to investigate the pattern of fundus autofluorescence and the correlation with the genotypes in a population of 410 patients affected by different types of RP.


Patients selected from our RP database, including 410 subjects with different types of RP, autosomal dominant, autosomal recessive, sporadic, mitochondrial and sindromic, were examined for analysis of the pattern of fundus autofluorescence (SLO–HRA Heidelberg). Ophthalmologic examination included refraction, best visual acuity at distance, slit lamp examination, fundoscopy, fundus photography, computerized perimetry (Humphrey), microperimetry (Nidek) color vision (Lanthony Panel D 15 test) dark adaptometry (Goldmann–Weekers) and electroretinography.


. All patients under examination showed a variably sized parafoveal ring of autofluorescence together with visual function and fundus changes typical of RP. In a number of cases a "negative" ring, with absence of autofluorescence, was observed. The size of autofluorescence ring is correlated with the size of residual central visual field, but not with the age of patients. The pattern of autofluorescence was not correlated with the genotype.


A parafoveal ring of autofluorescence may represent a reliable diagnostic clinical parameter in RP, predicting the extent of photoreceptor degeneration in the the macular area.



Keywords: retinal degenerations: hereditary • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • macula/fovea 

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