May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Application of Hollow–fiber Membrane for a New Glaucoma Drainage Device–Optimal Permeability for Intraocular Pressure Reduction
Author Affiliations & Notes
  • K.–I. Yamamoto
    Chemical Engineering, Waseda University, Shinjuku–ku, Japan
  • Y. Morizane
    Cardiovascular Physiology,
    Ophthalmology,
    Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • S. Mohri
    Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry, Shinjuku–ku, Japan
  • T. Miyasaka
    Cardiovascular Physiology,
    Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • I. Takasu
    Ophthalmology,
    Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • J. Shimizu
    Cardiovascular Physiology,
    Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • S. Takashima
    Orthopedic Surgery,
    Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • K. Sakai
    Chemical Engineering, Waseda University, Shinjuku–ku, Japan
  • H. Ohtsuki
    Ophthalmology,
    Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • F. Kajiya
    Cardiovascular Physiology,
    Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • Footnotes
    Commercial Relationships  K. Yamamoto, None; Y. Morizane, None; S. Mohri, None; T. Miyasaka, None; I. Takasu, None; J. Shimizu, None; S. Takashima, None; K. Sakai, None; H. Ohtsuki, None; F. Kajiya, None.
  • Footnotes
    Support  Industrial Technology Research Grant Program in '03 from NEDO of Japan
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 79. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      K.–I. Yamamoto, Y. Morizane, S. Mohri, T. Miyasaka, I. Takasu, J. Shimizu, S. Takashima, K. Sakai, H. Ohtsuki, F. Kajiya; Application of Hollow–fiber Membrane for a New Glaucoma Drainage Device–Optimal Permeability for Intraocular Pressure Reduction . Invest. Ophthalmol. Vis. Sci. 2005;46(13):79.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose:Implantation of drainage device has been established as a therapy for glaucoma patients. We propose a new glaucoma drainage device comprising hollow–fiber membrane and silicone tube to reduce intraocular pressure (IOP) by draining aqueous humor to the conjunctival fornix without causing infection. The objective of the present study is to evaluate water permeability of hollow–fiber membranes and to determine the hollow–fiber membrane suited to reduce IOP. Methods:We assembled mini–modules composed of hollow–fiber membrane (10 cm long, 100 fibers). The materials of hollow–fiber membrane targeted for this study were regenerated cellulose, polysulfone, cellulose triacetate, and polyester polymer alloy (PEPA). We measured filtration rate of each membrane under physiological conditions of the eye (310 K, 10 mmHg) using artificial aqueous humor (oxiglutatione, Senju pharmaceutical, Japan). Results:Mini–module composed of PEPA membrane showed the highest water permeability than other membranes (793 ± 48 ml/m2 hr mmHg). The water permeability of prototype of our drainage device, which composed of PEPA membrane (20 mm long, 1 fiber), was 2.6 ± 0.4 µl/min (n = 8). In our calculation, this prototype drainage can reduce IOP from 40 mmHg to 15 mmHg in 60 minutes. Conclusions: The new drainage device composed of PEPA membrane should be useful in reducing IOP effectively.

Keywords: intraocular pressure • aqueous 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×