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K.–I. Yamamoto, Y. Morizane, S. Mohri, T. Miyasaka, I. Takasu, J. Shimizu, S. Takashima, K. Sakai, H. Ohtsuki, F. Kajiya; Application of Hollow–fiber Membrane for a New Glaucoma Drainage Device–Optimal Permeability for Intraocular Pressure Reduction . Invest. Ophthalmol. Vis. Sci. 2005;46(13):79.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:Implantation of drainage device has been established as a therapy for glaucoma patients. We propose a new glaucoma drainage device comprising hollow–fiber membrane and silicone tube to reduce intraocular pressure (IOP) by draining aqueous humor to the conjunctival fornix without causing infection. The objective of the present study is to evaluate water permeability of hollow–fiber membranes and to determine the hollow–fiber membrane suited to reduce IOP. Methods:We assembled mini–modules composed of hollow–fiber membrane (10 cm long, 100 fibers). The materials of hollow–fiber membrane targeted for this study were regenerated cellulose, polysulfone, cellulose triacetate, and polyester polymer alloy (PEPA). We measured filtration rate of each membrane under physiological conditions of the eye (310 K, 10 mmHg) using artificial aqueous humor (oxiglutatione, Senju pharmaceutical, Japan). Results:Mini–module composed of PEPA membrane showed the highest water permeability than other membranes (793 ± 48 ml/m2 hr mmHg). The water permeability of prototype of our drainage device, which composed of PEPA membrane (20 mm long, 1 fiber), was 2.6 ± 0.4 µl/min (n = 8). In our calculation, this prototype drainage can reduce IOP from 40 mmHg to 15 mmHg in 60 minutes. Conclusions: The new drainage device composed of PEPA membrane should be useful in reducing IOP effectively.
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