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R.M. Lieberman, V.M. Chen, J.C. Lew, A. Young, R.M. Fischer; Optical Coherence Tomography (OCT) Findings in Long Term HIV Survivors . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1026.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate the retinal thickness in patients known to be HIV positive for up to 20 years, using OCT, and to investigate a possible correlation between duration of HIV disease and retinal thickness. Methods: A retrospective chart review and analysis was performed on 129 eyes of 67 consecutive HIV positive patients. OCT measurements were done with a Zeiss Stratus, model 3000, version 3.0. Data was analyzed using Microsoft Excel and NCSS. The patients were divided into 4 groups based on duration of HIV disease: 0–5 years, 5–10 years, 10–15 years, 15–20 years. The mean average total retinal thickness (TRT) and retinal nerve fiber layer thickness (RNFL) were calculated for each group and then compared. In addition, the following data was collected: age, race, CD–4 count, viral load, history of cytomegaloviral retinitis (CMVR), and history or presence of other retinal diseases. Retinal thickness was also compared to literature standards of HIV negative patients. Results: Analyses were performed both including and excluding patients with a history of CMVR. When these patients were excluded, we found a mean average total retinal thickness of 231.5 microns +/–8.79 and a mean retinal nerve fiber layer thickness of 29.5 microns +/– 8.33 for all four groups. ANOVA revealed no significant difference of the mean values for TR thickness (p= 0.34) and RNFL thickness (p= 0.91) between any of the four groups. Correlation coefficients were as follows: Age and TR thickness –0.15; Age and RNFL thickness –0.11; Duration of HIV and TR thickness +0.12, Duration of HIV and RNFL thickness –0.19; CD4 and TR thickness +0.09; CD4 and RNFL thickness –0.19; Duration of HIV and Viral Load –0.15. The mean age was 49 years, with a mean CD–4 count of 359. Patients with CMVR appeared to have significantly lower values, with a mean average TRT of 154.26+/–61.62. Conclusions:We found there to be no significant difference in retinal thickness amongst patients grouped according to the duration of their known HIV infection when patients with a history of CMVR were excluded. No strong correlations were found between the duration of HIV disease or the CD4 count, and retinal thickness. Mean retinal thickness was found to be lower than the reported standards in the literature for the same OCT device and program, but was within the reported standard deviation. CMVR, however, appears to decrease the TRT, irrespective of duration of HIV infection.
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