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J.S. Werner, R.J. Zawadzki, M. Zhao, J.A. Izatt; Three–Dimensional Retinal Imaging With High Speed and High Resolution OCT . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1052.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To demonstrate the performance of state–of–the–art Fourier domain optical coherence tomography (OCT) in clinical settings and to test its efficacy for three–dimensional (3D) imaging of retinal structures in vivo. Methods: Imaging was based on a Fourier domain optical coherence tomography system using a superluminescent diode centered at 840 nm with 50 nm optical bandwidth (6 µm axial resolution) operating at 10,000 A–scans/s. Three–dimensional (3D) reconstructions using custom software were based upon a series of images that were registered to remove motion artifacts. Results: Retinal structures (optic nerve head, fovea, retinal blood vessels) of healthy normal subjects were compared with standard B–scan and C–scan en face 2D visualization modes used in most clinical imaging systems. The 3D images provided a more comprehensive visualization of retinal structures. Conclusions: The high speed of Fourier domain OCT permits fast 3D data acquisition, making it possible for use in clinical settings. The 3D visualization of the retinal structures facilitates visualization of structure and opens the possibility for better diagnosis and monitoring of therapeutic interventions.
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