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B.E. K. Klein, R. Klein, K.E. Lee, M.D. Knudtson; Markers of Inflammation, Endothelial Dysfunction, and Age–Related Cataract . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1098.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To examine the association of systemic markers of inflammation and endothelial dysfunction with age–related cataract. Design: Prevalence and incidence findings from a random sample of a population–based cohort. Methods: A random sample of 396 persons was selected from participants at the baseline examination of the Beaver Dam Eye Study cohort. Standardized protocols for blood collection, measurement of serum markers, administration of a questionnaire, and gradings of color lens photographs to determine presence and severity of nuclear, cortical, and posterior subcapsular cataracts were used. Serum specimens were stored at –80°C. Of the 396 samples at baseline, 231 were eligible for incident nuclear, 236 for cortical, and 270 for posterior subcapsular cataract. The markers we evaluated were: high sensitivity C–reactive protein (hsCRP), serum amyloid A (SAA), tumor necrosis factor alpha (TNF–α), white blood cell count (WBC), albumen, interleukin–6 (IL–6), intercellular adhesion molecule (ICAM–1), E–selectin, and folate. Results: When controlling for age and sex, levels of TNF–α, IL–6, and ICAM–1 were associated with prevalent nuclear cataract (OR for change of one quartile =1.34, 1.45, 2.17, respectively). These associations were not significant for incident nuclear cataract. High serum folate levels were protective against incident nuclear cataract (OR=0.39). Many of the relationships did not appear to be linear and some were compatible with threshold effects. There were no significant associations between these markers and cortical or posterior subcapsular cataract. Conclusions: Some serum markers of systemic inflammation and endothelial dysfunction were associated with prevalent nuclear cataract. Using similar statistical models, these markers were not significantly related to incidence of this type of cataract. It is possible that mortality and cataract surgery have affected the incidence findings. In addition, the diminished number of subjects for incidence has reduced the power for these analyses. It is also possible that the prevalence findings are a result of chance.
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