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V.J. Srinivasan, M. Wojtkowski, T.H. Ko, M.T. Carvalho, A.J. Witkin, J.S. Schuman, J.S. Duker, J.G. Fujimoto; Intraretinal Thickness Mapping using Three–Dimensional, High–Speed Ultrahigh Resolution OCT . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1113.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To demonstrate new three–dimensional OCT (3D OCT) imaging and mapping of intraretinal layers in normal and pathologic eyes using high–speed, ultrahigh resolution optical coherence tomography. To present new techniques for quantifying and visualizing 3D OCT data. Methods: A high–speed, ultrahigh resolution OCT system using new "spectral/Fourier domain" detection methods has been developed for use in the ophthalmology clinic. This system achieves an improvement in imaging speed of 60x over commercial StratusOCT systems. Using broadband light sources, an axial image resolution of ∼3um is achieved. Imaging is performed on normal and pathologic eyes. Intraretinal layers and other features are quantified and displayed as false color en face maps. Maps are displayed alongside or overlaid on an OCT fundus image generated from three–dimensional data, enabling precise registration of maps with features on the fundus. Results: High–speed, ultrahigh resolution OCT imaging has been performed in normal subjects and a cross section of patients with retinal diseases. Retinal pathologies including macular hole, epiretinal membrane, macular edema, diabetic retinopathy, age–related macular degeneration, and central serous chorioretinopathy have been imaged. Segmentation and mapping of 3D OCT data was demonstrated in normal and pathologic eyes. The inner limiting membrane, nerve fiber layer, ganglion cell layer, inner and outer plexiform and nuclear layers, external limiting membrane, photoreceptor inner and outer segment junction, and retinal pigment epithelium were well–visualized in cross–sectional images and were measured for mapping. Conclusions: 3D OCT retinal imaging and mapping have been achieved with high–speed, ultrahigh resolution OCT. Measurements such as nerve fiber layer thickness, optic disk topography, and macular thickness can be performed with improved coverage and resolution compared to standard OCT. Quantification and mapping of intraretinal layer thicknesses or small microstructural features is also possible with improved coverage, enabling improved visualization of small pathologic changes such as disruptions in the retinal pigment epithelium or photoreceptors.
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