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J.G. Odel, C. Rodarte, E.B. Yang, X. Zhang, M.M. Behrens, J.Y. Chen, D.C. Hood; A Quantitative Measure of Multifocal Visual Evoked Potential Latencies in Ischemic Optic Neuropathy and Optic Neuritis . Invest. Ophthalmol. Vis. Sci. 2005;46(13):642.
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Purpose:To apply a quantitative measure of multifocal visual evoked potential (mfVEP) latencies to ischemic optic neuropathy (ION) and optic neuritis (ON). Quantitative measures of mfVEP amplitude have been developed and used to distinguish patients with areas of depressed responses [1,2]. However, quantitative measures of latency have not been as rigorously developed, despite possible applications to diagnosis and follow up of optic nerve diseases such as ION and ON. Methods: Three groups were tested: control (N=50), ION (N=21), and ON (N=23). Only one eye of the ON and ION patients was symptomatic. Monocular mfVEPs were obtained for both eyes of all subjects using the VERIS (EDI) system. Three channels of recording were analyzed using software previously described . Both monocular and interocular measures of latency were developed . Signal to noise ratio and wave–form criteria were used to exclude unreliable latencies. Confidence intervals (1% and 5%) were calculated using a normative group of 100 . Probability plots for latency were developed analogous to those described previously for amplitude measures . Results: Median interocular latencies were: –0.2 ms (control), 2.1 ms (ION), and 11.5 ms (ON). Median monocular latencies were: 1.9 ms (control), 2.2 ms (ION), and 11.0 ms (ON). A cluster of four abnormal points at the 1% significance level on the monocular or interocular probability plots gave positive rates of 4% (control), 5% (ION), and 83% (ON). Conclusions: Quantitative latency measures for the mfVEP can identify latency delays in patients with either ON or ION . Although latency delays for the two groups overlap, mfVEP latency combined with cluster criteria can help distinguish ON from ION. 1. Goldberg et al. (2002) AJO. 2. Hood & Greenstein (2003) Prog. Ret. Eye Res. 3. Hood et al. in press. Doc. Ophth. 4. Fortune et al. in press. Doc. Ophth. 5. Gih et al. (2004) ARVO.
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