May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
A Quantitative Measure of Multifocal Visual Evoked Potential Latencies in Ischemic Optic Neuropathy and Optic Neuritis
J.G. Odel; C. Rodarte; E.B. Yang; X. Zhang; M.M. Behrens; J.Y. Chen; D.C. Hood
Author Affiliations & Notes
  • J.G. Odel
    Ophthalmology,
    Columbia University, New York, NY
  • C. Rodarte
    Psychology,
    Columbia University, New York, NY
  • E.B. Yang
    Psychology,
    Columbia University, New York, NY
  • X. Zhang
    Psychology,
    Columbia University, New York, NY
  • M.M. Behrens
    Ophthalmology,
    Columbia University, New York, NY
  • J.Y. Chen
    Psychology,
    Columbia University, New York, NY
  • D.C. Hood
    Psychology,
    Columbia University, New York, NY
  • Footnotes
    Commercial Relationships  J.G. Odel, None; C. Rodarte, None; E.B. Yang, None; X. Zhang, None; M.M. Behrens, None; J.Y. Chen, None; D.C. Hood, None.
  • Footnotes
    Support  NIH Grant EY02115
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 642. doi:
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      J.G. Odel, C. Rodarte, E.B. Yang, X. Zhang, M.M. Behrens, J.Y. Chen, D.C. Hood; A Quantitative Measure of Multifocal Visual Evoked Potential Latencies in Ischemic Optic Neuropathy and Optic Neuritis . Invest. Ophthalmol. Vis. Sci. 2005;46(13):642.

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Abstract

Abstract: : Purpose:To apply a quantitative measure of multifocal visual evoked potential (mfVEP) latencies to ischemic optic neuropathy (ION) and optic neuritis (ON). Quantitative measures of mfVEP amplitude have been developed and used to distinguish patients with areas of depressed responses [1,2]. However, quantitative measures of latency have not been as rigorously developed, despite possible applications to diagnosis and follow up of optic nerve diseases such as ION and ON. Methods: Three groups were tested: control (N=50), ION (N=21), and ON (N=23). Only one eye of the ON and ION patients was symptomatic. Monocular mfVEPs were obtained for both eyes of all subjects using the VERIS (EDI) system. Three channels of recording were analyzed using software previously described [2]. Both monocular and interocular measures of latency were developed [3]. Signal to noise ratio and wave–form criteria were used to exclude unreliable latencies. Confidence intervals (1% and 5%) were calculated using a normative group of 100 [4]. Probability plots for latency were developed analogous to those described previously for amplitude measures [2]. Results: Median interocular latencies were: –0.2 ms (control), 2.1 ms (ION), and 11.5 ms (ON). Median monocular latencies were: 1.9 ms (control), 2.2 ms (ION), and 11.0 ms (ON). A cluster of four abnormal points at the 1% significance level on the monocular or interocular probability plots gave positive rates of 4% (control), 5% (ION), and 83% (ON). Conclusions: Quantitative latency measures for the mfVEP can identify latency delays in patients with either ON or ION [5]. Although latency delays for the two groups overlap, mfVEP latency combined with cluster criteria can help distinguish ON from ION. 1. Goldberg et al. (2002) AJO. 2. Hood & Greenstein (2003) Prog. Ret. Eye Res. 3. Hood et al. in press. Doc. Ophth. 4. Fortune et al. in press. Doc. Ophth. 5. Gih et al. (2004) ARVO.

Keywords: electrophysiology: clinical • neuro-ophthalmology: optic nerve 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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