May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Sleep Apnea, the Most Frequent Disorder Associated With Nonarteritic Anterior Ischemic Optic Neuropathy
Author Affiliations & Notes
  • E. Renard
    Ophthalmology,
    University Hospital, Grenoble, France
  • K. Palombi
    Ophthalmology,
    University Hospital, Grenoble, France
  • J.–L. Pepin
    Sleep Laboratory and EFCR,
    University Hospital, Grenoble, France
    H2P Laboratory, INSERM ESPRI EA 3745 (Hypoxia: Physiopathology), Joseph Fourier University, Grenoble, France
  • P. Levy
    Sleep Laboratory and EFCR,
    University Hospital, Grenoble, France
    H2P Laboratory, INSERM ESPRI EA 3745 (Hypoxia: Physiopathology), Joseph Fourier University, Grenoble, France
  • C. Dechaux
    Sleep Laboratory and EFCR,
    University Hospital, Grenoble, France
    H2P Laboratory, INSERM ESPRI EA 3745 (Hypoxia: Physiopathology), Joseph Fourier University, Grenoble, France
  • C. Chiquet
    Ophthalmology,
    University Hospital, Grenoble, France
  • M. Mouillon
    Ophthalmology,
    University Hospital, Grenoble, France
  • J.–P. Romanet
    Ophthalmology,
    University Hospital, Grenoble, France
  • Footnotes
    Commercial Relationships  E. Renard, None; K. Palombi, None; J. Pepin, None; P. Levy, None; C. Dechaux, None; C. Chiquet, None; M. Mouillon, None; J. Romanet, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 644. doi:
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      E. Renard, K. Palombi, J.–L. Pepin, P. Levy, C. Dechaux, C. Chiquet, M. Mouillon, J.–P. Romanet; Sleep Apnea, the Most Frequent Disorder Associated With Nonarteritic Anterior Ischemic Optic Neuropathy . Invest. Ophthalmol. Vis. Sci. 2005;46(13):644.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To evaluate newly diagnosed Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) patients for the existence of sleep apnea. Methods: Polysomnography allowed determining the prevalence rate of sleep apnea in NAION patients. The prevalence found in the study was compared to historical controls. Hypertension, diabetes, hyperlipidemia, atheromatous lesions of carotid vessels and inflammatory diseases being all classical risk factors associated with NAION were also identified. Results: Twenty–five consecutive newly diagnosed NAION patients (16 men, mean age 66±8 years, body mass index 27.3±3.9 kg/m2) were included in the study. Eighty–eight percent of the patients exhibited a sleep apnea syndrome (Respiratory disturbace index: 35.5±16.6/h). Risk ratio (RR) for a NAION patient to suffer from sleep apnea was 4.9 compared to historical controls (p<0.001). Sleep apnea was 1.5 to 2 fold more frequent than the rate of the other identified risk factors classically associated with NAION (i.e. hypertension, diabetes). Continuous positive airway pressure (nCPAP) treatment was prescribed in 68% of the patients with a 6.1/h per day compliance rate. Conclusions: Sleep apnea is the most frequent disorder associated with NAION and should be systematically investigated in this population.The association between both diseases may be explained by similar vascular pathophysiological mechanisms.

Keywords: neuro-ophthalmology: optic nerve • clinical (human) or epidemiologic studies: prevalence/incidence • hypoxia 
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