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E. Renard, K. Palombi, J.–L. Pepin, P. Levy, C. Dechaux, C. Chiquet, M. Mouillon, J.–P. Romanet; Sleep Apnea, the Most Frequent Disorder Associated With Nonarteritic Anterior Ischemic Optic Neuropathy . Invest. Ophthalmol. Vis. Sci. 2005;46(13):644.
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Purpose: To evaluate newly diagnosed Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) patients for the existence of sleep apnea. Methods: Polysomnography allowed determining the prevalence rate of sleep apnea in NAION patients. The prevalence found in the study was compared to historical controls. Hypertension, diabetes, hyperlipidemia, atheromatous lesions of carotid vessels and inflammatory diseases being all classical risk factors associated with NAION were also identified. Results: Twenty–five consecutive newly diagnosed NAION patients (16 men, mean age 66±8 years, body mass index 27.3±3.9 kg/m2) were included in the study. Eighty–eight percent of the patients exhibited a sleep apnea syndrome (Respiratory disturbace index: 35.5±16.6/h). Risk ratio (RR) for a NAION patient to suffer from sleep apnea was 4.9 compared to historical controls (p<0.001). Sleep apnea was 1.5 to 2 fold more frequent than the rate of the other identified risk factors classically associated with NAION (i.e. hypertension, diabetes). Continuous positive airway pressure (nCPAP) treatment was prescribed in 68% of the patients with a 6.1/h per day compliance rate. Conclusions: Sleep apnea is the most frequent disorder associated with NAION and should be systematically investigated in this population.The association between both diseases may be explained by similar vascular pathophysiological mechanisms.
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