May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
The Effects of Quantitative Zonular Stretching on the Topography of the Anterior Surface of Porcine Lenses
Author Affiliations & Notes
  • P.D. Hamilton
    Research, Veterans Affairs Medical Center JC, St Louis, MO
  • N. Ravi
    Department of Ophthalmology & Visual Sciences, Washington University, St Louis, MO
    Surgery, Veterans Affairs Medical Center JC, St. Louis, MO
  • G. Perry
    Department of Ophthalmology & Visual Sciences, Washington University, St Louis, MO
  • M. Reilly
    Chemical Engineering, Washington Unversity, St Louis, MO
  • Footnotes
    Commercial Relationships  P.D. Hamilton, None; N. Ravi, None; G. Perry, None; M. Reilly, None.
  • Footnotes
    Support  VA Merit Review, Nathan Ravi, Research for the Prevention of Blindness
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 738. doi:
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    • Get Citation

      P.D. Hamilton, N. Ravi, G. Perry, M. Reilly; The Effects of Quantitative Zonular Stretching on the Topography of the Anterior Surface of Porcine Lenses . Invest. Ophthalmol. Vis. Sci. 2005;46(13):738.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Abstract:
 

We plan to investigate the effect of radial zonular stretching on changes of the anterior lens surface utilizing a corneal topographer.

 

We previously described a computer–controlled dynamic–radial lens stretcher equipped with linear stepper motors and force sensors. Porcine eyes were embedded in soft agar to maintain the physiological shape. After excision of the cornea, an initial topography reading of the anterior lens surface was determined. Subsequently, the lens and the ciliary body were dissected out, and placed in the 4–arm stretcher, with clamps attached to the ciliary body. As the lens was strained by a known amount using the stepper motors, the dynamic force–relaxation was noted and topographical measurements were acquired.

 

Increasing the zonular tension resulted in the flattening of the central as well as the peripheral curvature of the anterior lens surface. The force–relaxation curve was fitted well with two time constants (τ1 = 65 ± 11 ms, τ2 = 816 ± 59 ms). The figure presents force–relaxation curves showing corresponding changes of radius of curvature in the central portion of the lens.

 

Our results demonstrate lens flattening with increased zonular tension, which is consistent with Helmoltz’s theory of accommodation.

 

 

 
Keywords: anterior segment • ciliary body • refraction 
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