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F.A. Bucci, R.E. Evans, L.M. Amico; Comparison of Ketorolac 0.5%, Ketorolac 0.4%, and Diclofenac 0.1% – Combined With Prednisolone 0.1% on Aqueous Flare Following Cataract Surgery . Invest. Ophthalmol. Vis. Sci. 2005;46(13):789.
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Purpose: To compare the efficacy of ketorolac 0.5% (Acular TM, Allergan Inc.) ketorolac 0.4% (Acular LS®, Allergan Inc.) and diclofenac sodium 0.1% (Voltaren®, Novartis) when used in conjunction with prednisolone 0.1% (Pred Forte®, Allergan, Inc.) for controlling mild to severe inflammation, as measured by aqueous flare, following cataract surgery. Methods:Sixty seven patients were randomized to three NSAID formulations in conjunction with a topical steroid: 1) Acular TM + Pred Forte (n = 22) 2) Acular LS® + Pred Forte (n = 22) and 3) Voltaren + Pred Forte (n = 23) which were dosed QID for 2 days prior to surgery then Q 10 minutes x 4 doses beginning 1 hour prior to surgery, and then QID for 2 weeks after surgery. A KOWA flare meter (Keeler Ltd., Berkshire, UK) was used to measure aqueous flare 1 day, 1 week, and 2 weeks postoperatively. Results:Flare results (expressed in p/msec) are as follows for the 1 day, 1 week, and 2 week postop visits, respectively. 1) Acular + Pred Forte: 26.8 /19.3 / 13.4 2) Acular LS + Pred Forte: 38.8 / 22.4 / 14.6 3) Voltaren + Pred Forte: 37.5 / 25.4 / 18.1 No statistically significant differences were found in postoperative flare between these three therapeutic regimens at any of the 3 postop periods measured. Conclusions: There were no significant differences in the efficacy of Acular vs. Acular LS when used in combination with Pred Forte. The combination of Voltaren + Pred Forte was not significantly more effective than either Acular or Acular LS with Pred Forte.
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