May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Evidence Based Analysis of the Performance of Blue Light–Filtering IOL in Various Lighting Conditions for Visual Acuity, Colorvision, Contrast Sensitivity, Contrast Enhancement, and Quality of Life
Author Affiliations & Notes
  • J.P. McCulley
    Ophthalmology, Univ of TX Southwestern–Dallas, Dallas, TX
  • Footnotes
    Commercial Relationships  J.P. McCulley, Alcon Laboratories C, R.
  • Footnotes
    Support  RPB unrestricted grant
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 807. doi:
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      J.P. McCulley; Evidence Based Analysis of the Performance of Blue Light–Filtering IOL in Various Lighting Conditions for Visual Acuity, Colorvision, Contrast Sensitivity, Contrast Enhancement, and Quality of Life . Invest. Ophthalmol. Vis. Sci. 2005;46(13):807.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To define and assess the visual functional performance of blue light filtering IOL compared to conventional UV–only filtering IOL using the following as surrogates: visual acuity, color vision, contrast sensitivity, contrast enhancement, and Quality of Life (QoL) study. Methods: FDA clinical study results and a search of peer–reviewed and trade literature articles published between 1990 and late 2004, assessing the visual performance of blue light filtering IOL compared to UV–only filtering IOLs. Meta–analysis of the literature findings was done. Results: Blue light–filtering IOL technology provides equal, to better visual performance under photopic, and mesopic lighting conditions, for patients after cataract surgery. 1 yr. post–op 75.6% of blue light–filtering IOL clinical trial subjects achieved BCVA of 20/20 or better compared to 74.0% for control UV–only filtering IOL subjects. FDA clinical trials used Farnsworth D15; and post–market FM 100 test with no statistical difference in implanted patient color vision for blue light–filtering IOL vs. UV–only filtering IOL. Contrast sensitivity (CSV–1000E), 120–180 days after 2nd eye implantation under photopic and mesopic lighting conditions, found no statistical difference at 3, 6, 12, and 18 cycles per degree (cpd) between blue light–filtering and UV–only filtering IOL patients in the FDA clinical study, respectively. Other peer–reviewed research has found significantly higher contrast sensitivities among blue–light filtering IOL patient groups at frequencies of 1.5, 3, and 6 cpd, vs. UV–only filtering IOL patient groups under mesopic light conditions. Results based on laboratory studies of blue light–filtering IOL vs. UV–only–filtering IOL showed a 47%, 21%, and 21% contrast enhancement increase for red, green, and blue colors, due to reduced chromatic aberration. QoL study (NEI VFQ–39) found bilaterally implanted blue–light filtering IOL and UV–only IOL patient comparisons comparable with a mean 99.4% vs. 98.6% rating for color vision, respectively, and a mean 91.2% vs. 90.0% rating for driving, respectively. (Scale ratings of 0–100. Higher scores equal more favorable vision–targeted QoL). Conclusions: Visual acuity, color vision, contrast sensitivity, contrast enhancement, and QoL study results are excellent surrogates for visual performance of blue light–filtering IOL in various lighting conditions, as determined through these data in comparison to UV–only filtering IOL.

Keywords: visual acuity • cataract • quality of life 
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