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M.W. Robboy, S. Groemminger, A. Dobie, K. Pierce, L. Stiffler; Water Retention in Dry Eye Subjects of Soft Contact Lenses Treated With Several Multi–purpose Solutions . Invest. Ophthalmol. Vis. Sci. 2005;46(13):922.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Three clinical evaluations were undertaken to assess whether changes in water content can be demonstrated in dry eye subjects following the wearing of Acuvue® 2 lenses soaked in Bausch & Lomb ReNu® with MoistureLocTM, when compared to Acuvue® 2 lenses soaked in Alcon Opti–Free® Express®, Ciba AQuify®, and AMO Complete® Moisture PlusTM multi–purpose solutions. Methods: 18, 20, and 20 dry eye subjects, all habitual soft spherical contact lens wearers with a computer–based visual analog dryness score of 60 or less on a 100–point scale, were each enrolled in a clinical evaluation. Test and control solution lenses were pre–treated in ReNu® with MoistureLocTM and in Alcon Opti–Free® Express®, Ciba AQuify®, and AMO Complete® Moisture PlusTM, respectively, in pre–treated lens cases. Each subject wore a test ReNu with MoistureLoc/ Acuvue® 2 lens and a control solution/ Acuvue® 2 lens on contralateral eyes for approximately 1 hour. After one hour, lenses were removed from the eye, and were immediately weighed on an analytical balance. Lenses were placed into a vacuum chamber overnight under pressure at ambient temperature and subsequently re–weighed. Results: In each of the three studies, the test lenses exhibited statistically less mean relative percent total water loss compared to the control lenses. The ReNu® with MoistureLocTM soaked test lenses lost (1) 5.4 percent of their total water content, while the Alcon Opti–Free® Express® soaked control lenses lost 7.6 percent of their total water content, (2) 5.1 percent of their total water content, while the Ciba AQuify® soaked control lenses lost 6.6 percent of their total water content, and (3) 5.7 percent of their total water content, while the AMO Complete® Moisture PlusTM soaked control lenses lost 6.8 percent of their total water content. Conclusions: The results of this study indicate that ReNu® with MoistureLocTM exhibits the capacity to decrease the level of lost water, in lenses worn by contact lens dry eye subjects.
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