May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Objective Measurement of Human Conjunctival Erythema by Spectroradiometry After Instillation of Irritants
Author Affiliations & Notes
  • L. Sharf
    Ophthalmology Research, Scripps Clinic, La Jolla, CA
  • D. Breshears
    Ophthalmology Research, Scripps Clinic, La Jolla, CA
  • M.H. Friedlaender
    Ophthalmology Research, Scripps Clinic, La Jolla, CA
  • Footnotes
    Commercial Relationships  L. Sharf, None; D. Breshears, None; M.H. Friedlaender, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 946. doi:
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      L. Sharf, D. Breshears, M.H. Friedlaender; Objective Measurement of Human Conjunctival Erythema by Spectroradiometry After Instillation of Irritants . Invest. Ophthalmol. Vis. Sci. 2005;46(13):946.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To objectively measure conjunctival erythema before and after instillation of irritant solutions. Methods: Conjunctival erythema was measured objectively with a spectroradiometer in 8 normal human subjects before and after instillation of 1:10 dilutions of pH balanced and non–pH balanced shampoos. Erythema of the bulbar conjunctiva was determined using the u' coordinate of the 1976 CIE chromaticity scale. Measurements were recorded 5, 10, and 15 minutes after instillation of irritants. Results: Conjunctival erythema, measured by u', increased after instillation of both pH balanced (2.4%) and non–pH balanced (8.2%) shampoo. The greatest amount of erythema was detected at the 5 minute interval. The increase in erythema was greater for non–pH balanced shampoo than for pH balanced shampoo at all time intervals (p<0.05). Conclusions: Increased conjunctival erythema can be measured objectively with spectroradiometry after instillation of irritant solutions.

Keywords: conjunctivitis • ocular irritancy/toxicity testing 
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