May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Anti–Inflammatory Effect of Atorvastatin in Experimental Autoimmunue Uveoretinitis
Author Affiliations & Notes
  • H. Kohno
    Ophthalmology,
    Jikei Univ Sch Med, Minatoku, Japan
  • T. Sakai
    Ophthalmology,
    Jikei Univ Sch Med, Minatoku, Japan
  • S. Saitou
    Molecular Immunology,
    Jikei Univ Sch Med, Minatoku, Japan
  • K. Kitahara
    Ophthalmology,
    Jikei Univ Sch Med, Minatoku, Japan
  • Footnotes
    Commercial Relationships  H. Kohno, None; T. Sakai, None; S. Saitou, None; K. Kitahara, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 966. doi:
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    • Get Citation

      H. Kohno, T. Sakai, S. Saitou, K. Kitahara; Anti–Inflammatory Effect of Atorvastatin in Experimental Autoimmunue Uveoretinitis . Invest. Ophthalmol. Vis. Sci. 2005;46(13):966.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Statins, which are 3–hydroxy–3–methyglutaryl coenzyme A (HMG–CoA) reductase inhibitors, are approved for cholesterol reduction and commonly used to treat atherosclerosis and coronary artery disease. Statins may also be potent immunomodulatory agents and be beneficial in the treatment of autoimmunue diseases. We investigated the effects of oral atorvastatin on experimental autoimmunue uveoretinitis (EAU). Methods: EAU was induced in Lewis rats with S antigen. Atorvastatin was suspended in 0.5% aqueous methylcellulose (MC). Atorvastatin was administered orally in 0.5 ml MC (10mg/kg) once daily for 20 days from the appearance of clinical signs. MC was administered as a control. The clinical scores were evaluated statistically 8 and 14 days after administration. Morphologic and immunohistochemical examinations with confocal microscope were done in all rats. Results: Atorvastatin decreased clinical and histological scores of EAU. Clinical scores in the atrovastatin–treated group were significantly lower than in the MC–treated group on day 8 (3.38 ± 0.75 and 2.00 ± 0.71, respectively, P =0.0011) and day 14 (1.65 ± 0.78 and 0.75 ± 0.60, respectively , P =0.0251). The invasion of T cells and the proliferation of Müller cells were inhibited in the atorvastatin–treated group. Conclusions: Atorvastatin significantly inhibited inflammation in EAU. Statins may be useful for treating intraocular inflammation.

Keywords: uveitis-clinical/animal model • inflammation • drug toxicity/drug effects 
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