May 2005
Volume 46, Issue 13
ARVO Annual Meeting Abstract  |   May 2005
Diurnal Variation of Intraocular Pressure in Suspected Normal–Tension Glaucoma
Author Affiliations & Notes
  • K. Kawase
    Ophthalmology, Gifu University, Gifu–shi, Japan
  • K. Hasegawa
    Ophthalmology, Gifu University, Gifu–shi, Japan
  • A. Sawada
    Ophthalmology, Gifu University, Gifu–shi, Japan
  • T. Yamamoto
    Ophthalmology, Gifu University, Gifu–shi, Japan
  • Footnotes
    Commercial Relationships  K. Kawase, None; K. Hasegawa, None; A. Sawada, None; T. Yamamoto, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 1302. doi:
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      K. Kawase, K. Hasegawa, A. Sawada, T. Yamamoto; Diurnal Variation of Intraocular Pressure in Suspected Normal–Tension Glaucoma . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1302.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: To identify the features of diurnal variation of intraocular pressure (IOP) in normal–tension glaucoma (NTG). Methods: A total of 575 patients were suspected to have NTG in Gifu University Hospital between 1989 and 2003 based on structural and functional abnormality indicating glaucoma but lacking high IOP (> 20 mmHg) and underlying pathology. Goldmann applanation tonometry was repeatedly performed for 24 hrs at 2–hr intervals without medication or after 4–week discontinuation of all medications. Results:Twenty–nine patients (5%) showed high IOP (≥ 21 mmHg) at least one eye during the IOP phasing. In the remaining 546 established NTG cases, the average, maximum and minimum IOPs were 13.9±2.0 mmHg (mean ± SD), 16.0±2.2 mmHg, and 11.7±2.1 mmHg, respectively. The diurnal variation ranged from 1 to 10 mmHg and averaged 4.3±1.6 mmHg. The peak IOP was recorded during 0800–1600 hrs in 66.6% of the cases and the trough during 2400–0400 hrs in 44.2%. In 13 patients (2.3%) out of 563 patients (97.2%) who showed all IOPs during office hours (1000–1600) within 20 mmHg, IOP was over 20 mmHg at least once outside of the office hours. Conclusions: Basic features of diurnal IOP variation in NTG have been elucidated. Approximately 5% of all patients suspected NTG showed IOP over 20 mmHg during 24–hr IOP phasing.

Keywords: clinical research methodology • circadian rhythms 

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