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D.P. Fan, Z.–F. Fu, M.–Z. Zhang, X.–R. Liu, X.–B. Wu; The Pulsatile Ocular Flow in Primary Open Angle Glaucoma Patients Undergoing Trabeculectomy . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1339.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To compare the influence of pulsatile ocular blood flow (POBF) and intraocular pressure (IOP) on mean defect (MD) of visual field (VF) in patients with primary open angle glaucoma (POAG) before and after operation. Methods: Fifty–nine POAG patients who planned to receive trabeculectomy at Xiamen Eye Center were assessed by POBF tonometry, Goldman tonometer and Humphrey perimeter before and after operation, serially for at least 6 months. Linear regression analysis was applied to determine the relation among the change of POBF, IOP and MD of VF prior to and after therapy. Results:In all 59 cases, the mean follow up was 13.0 +/– 4.2 months (range: 7–21 months). There was a statistically significant relation between MD of VF and POBF (r=–0.023, p=0.031), while an insignificant relation was found between IOP and MD of VF (r=–0.008, p=0.210). Visual field and optic disc were stable in 34 cases and a highest statistically significant relation between MD of VF and POBF was found in these cases (r=0.034, p=0.017). POBF decrease in all those eyes (25 eyes) with VF loss and increase in cup–disc ratios during the follow–up period with an average value of 3.34+/–1.96 ul/sec(Mean+/–SD). Conclusions: POBF might be a better determinant of VF defect in POAG cases.
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