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H.–W. Kwak, S.–C. Lee, W.–H. Nam, S. Yu; Correlation of Preferential Hyperacuity Perimeter (PHP) With OCT and FA in Patients With Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1397.
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Purpose: The preferential hyperacuity perimeter (PHP) is a newly developed device that detects hyperacuity defect in the central 14° of macular visual field and may be beneficial for monitoring intermediate age–related macular degeneration (AMD) patients for development of CNV. The aim of this study was to elucidate hyperacuity defects of the PHP with Optical coherence tomography (OCT) and fluorescein angiography (FA) in patient with AMD. Methods: Nineteen eyes of 18 patients with advanced AMD diagnosed by fundus examination and FA underwent PHP. When the hyperacuity defect in the PHP appeared, OCT was performed and compared with the PHP results. As control, 20 eyes of 10 age–matched patients with no retinal disease underwent PHP and OCT. Results: Of 19 eyes with advanced AMD, 18 eyes (95%) had a positive test for hyperacuity defects. In 18 eyes with PHP defect, regional correlation between lesion location on the PHP and other examination was good in 16 eyes, and reversal in 2 eyes (superior–inferior and left–right). Hyperacuity defects in the PHP appeared as smooth or irregular elevation of the retinal pigment epithelium (RPE) in OCT. In the control, hyperacuity defect appeared in 1 eye (5%) but OCT finding was normal. Conclusions: This study demonstrated that the PHP is sensitive to detect advanced AMD and had good regional correlation of lesion location with OCT and FA. The hyperacuity defects in PHP appeared as a elevation of the RPE in OCT as previously proposed.
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