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M.A. Pericak–Vance, A. Agarwal, E.A. Postel, M. Klein, J. Haines, S. Schmidt, W. Scott, M. Hauser, P. Sternberg; Distribution of Age Related Macular Degeneration Lesions in Singleton and Multiplex Families . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1403.
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Purpose: To study and analyze the lesions of age related macular degeneration (AMD) in singleton and multiplex families Methods:Subjects with AMD were identified as part of an ongoing study at two academic centers. The macular findings were graded according to the modified Wisconsin grading used in the AREDS study. Data were analyzed with regard to age at presentation and severity of AMD grade. Eyes with grade 3 and above were included. Results:Of the total 1135 patients (2270 eyes), 398 belonged to the multiplex group (133 families), 97 to discordant sib pairs (45 families) and 650 were isolated affected patients. The age at examination ranged from 37–98 for the multiplex, 44–91 for the discordant sib–pair and from 47–107 for the singleton patients. In the multiplex group (573 eyes) there were 256 eyes with grade 5 (44%), 107 eyes with grade 4 (18%), and 210 eyes with grade 3 (38%) AMD. Amongst the discordant sib pairs (80 eyes), 48 eyes had grade 5 (60%), 11 eyes had grade 4 (14%) and 21 eyes had grade 3 (26%) AMD. Amongst the singletons (1058 eyes), 593 had grade 5 (56%), 167 had grade 4 (16%) and 1058 had grade 3 (28%) AMD. Conclusions: The distribution of the various grades of AMD seem to be comparable in the singleton and the discordant sib pairs, while the multiplex group tended to have fewer eyes with grade 5 and more eyes with grade 3.
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