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A. Yamashita, H. Nomoto, H. Yamaji, F. Shiraga; Effect of Intravitreal Triamcinolone Injection Combined With Vitrectomy on Macular Retinal Thickness in Eyes With Diabetic Macula Edema . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1450.
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Purpose: To evaluate the relation between the amount of intravitreal triamcinolone acetonide (TA) and recurrence of macular edema after combined vitrectomy and triamcinolone acetonide (TA) injection in eyes with diabetic macula edema (DME). Methods: The vitrectomy was performed and TA was injected into vitreous cavity at the end of surgery in 17 consecutive eyes with DME. All eyes received intravitreal injection of either 4mg of TA in 0.1ml balanced salt solution (group V4; 6 eyes) or 8mg of TA in 0.2ml balanced salt solution (group V8; 11 eyes). Macular retinal thickness was measured using optical coherence tomography (OCT 3). Results: In V4 group, macular retinal thickness was 620.1±95.9µm (mean±SD) at baseline, 308.9±167.3µm at 7 days, and 517.3±173.8µm at 3 months. The macular retinal thickness decreased significantly from baseline at 7 days (paired t test; p= 0.008), but it increased at 3 months (p= 0.008, between at 7 days and at 3 months). In V8 group, the macular retinal thickness was 512.5±170.5µm at baseline, 379.3±155.2µm at 7 days, and 342.5±172.1µm at 3 months. The macular retinal thickness decreased significantly for 3 months after surgery compared with baseline (p<0.01). Recurrence, defined as increase in macular retinal thickness by 100µm or more, was seen at 3 months in 5 of 6 eyes in V4 group and in 1 of 11 eyes in V8 group. Conclusions: Intravitreal injection of 8mg of TA at the end of vitrectomy could prevent or delay the recurrence of DME.
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