May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Design and Characterization of a Pneumatic Multichannel Microfluidic Release Control System for Neutrotransmitter–Based Retinal Prostheses
Author Affiliations & Notes
  • T.M. Raza
    Ophthalmology, Kresge Eye Institute, Wayne State University, Detroit, MI
    Ligon Research Center of Vision, Detroit, MI
  • E. Sendler
    Ophthalmology, Kresge Eye Institute, Wayne State University, Detroit, MI
    Ligon Research Center of Vision, Detroit, MI
  • G.W. Abrams
    Ophthalmology, Kresge Eye Institute, Wayne State University, Detroit, MI
    Ligon Research Center of Vision, Detroit, MI
  • R. Iezzi
    Ophthalmology, Kresge Eye Institute, Wayne State University, Detroit, MI
    Ligon Research Center of Vision, Detroit, MI
  • Footnotes
    Commercial Relationships  T.M. Raza, None; E. Sendler, None; G.W. Abrams, Wayne State University P; R. Iezzi, Wayne State University P.
  • Footnotes
    Support  RPB Career Development Award, Ligon Research Center of Vision, NIH LRP
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 1502. doi:
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    • Get Citation

      T.M. Raza, E. Sendler, G.W. Abrams, R. Iezzi; Design and Characterization of a Pneumatic Multichannel Microfluidic Release Control System for Neutrotransmitter–Based Retinal Prostheses . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1502.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To design and characterize a multichannel computer–controlled pneumatic puffing system for use with neurotransmitter–based retinal prostheses. Methods: Three subsystems were designed. Nitrogen–driven pneumatic circuits were built from four–channel modules comprized of a pneumatic filter/capacitor, pressure regulator, and four–channel manifold with one electronic solenoid valve per channel. A pneumatic pressure transducer connected to the output of the pressure regulator allowed precise adjustment of ejection pressure. Electronic solenoid valves were controlled via solid–state relays connected to a high–speed complex–programmable logic device (CPLD). Spatial and temporal stimulation patterns were loaded into a dual–port RAM via a USB 2.0 interface. Stimulus movies were played back from RAM via the CPLD. Results: A 32–channel pneumatic control system was built. Minimum puff duration was 20 milliseconds. Typically 20 psi of pressure was required to eject fluorescein from 0.5 micron lumen pipettes. Diffferences in fluorescein release between microfluidic orifices were normalized using look up tables resident within the dual–port RAM. Conclusions: We have designed and built a scalable microfluidic release control system that incorporates software, hardware and pneumatic subsystems. Look–up table linearization of drug release was possible due to the digital control system.

Keywords: neurotransmitters/neurotransmitter systems • retina: neurochemistry • retina: proximal (bipolar, amacrine, and ganglion cells) 
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