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H. Tomita, E. Sugano, M. Sato, H. Kurino, Y. Usui, J. Deguchi, T. Watanabe, K. Motonami, M. Koyanagi, M. Tamai; Electrical Stimulation of the Rabbit Retina With Epi–Retinal Implanted Electrode Arrays . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1508.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:We have been developing new type retinal prosthesis chip based on three dimensional (3D) structures. The characteristic feature of this chip is a one–piece implantable device with the function of photodetection, image processing, stimulus current generation, and an electrode array on one LSI chip. The purpose of this study is to evaluate the function of this chip in the rabbit retina. Methods:Adult Japanese White (JW) rabbits were anesthetized for the implantation of 4X4 electrodes array onto retina. After simple vitrectomy the electrodes array was implanted onto retinal surface fixing with retinal tacks. To record electrically evoked potential (EEP), one day before the implantation of electrode arrays, silver electrode was placed as active electrode epidurally 4 mm anterior and 5 mm lateral on each side of lambda, and the reference electrode was placed epidurally on the midline 25 mm anterior to lambda. The grand electrode needle was subcutaneously placed on the nose. The other end of the implanted electrodes array was connected to a computer–controlled stimulator device. The retina was stimulated at various current. Results: EEPs were recorded at the range of current from 100 µA to 500µA. We examined changes of retinal morphology after acute electrostimulations. Obvious retinal damages were observed at 500 µA stimulation. No damage was seen in retinas stimulated under 200 µA. Our result revealed that the damage to retina was not caused by the manner of implantation, but electrostimulation of 500µA. Conclusions: We established the technique for epiretinal implant of our developed device. The one–piece implantable device could stimulate ganglion cells in the rabbit retina. Taken together with results of biocompatibility, our device could be useful to restore vision for blind patients.
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