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H. Chung, S. Paik, A. Lee, J.–M. Seo, E. Kim, J. Lim, D. Cho, S. Kim, H. Yu, Y.S. Yu; Revised Silicon Retinal Tack for Epiretinal Fixation of the Electrode . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1514.
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Purpose: Silicon–micromachined retinal tacks were revised for the easy operation. In vivo experiments were done on rabbit eyes to evaluate the usability and safety of implantation. Methods: Silicon retinal tacks were fabricated by using the silicon on insulator (SOI) process, a method of releasing silicon structures in a SOI wafer. The angle of the tip was reduced for easy insertion into the eye and the shape of the head was rounded to avoid fragmentation of the silicon retinal tacks during the operation. The tip taper angle is 30 degree and the dimensions of the retinal tack are 1.5 mm long, 150 µm wide, and 150 µm thick. The size and the shape of the barbing were modified for the convenience of the removal at the failure of the operation. Parylene was deposited on the surface of the retinal tack to enhance the durability and the biocompatibility. In vivo experiment was done in the eyes of an anesthetized rabbit. The silicon retinal tack was handled with end–gripping vitreous forceps and the polyimide electrode array was fixed epiretinally using the silicon tacks. Biocompatibility and the stability were checked during the follow–up period. Results: Revised silicon retinal tacks could be handled with ease and showed good penetration into the sclera by gentle snapping. For more than 6 months of follow–up period, epiretinally implanted polyimide electrode array and the silicon retinal tack did not show any movement or loosening of the implants. No melting or fragmentation of the silicon retinal tacks was found on the scanning electron microscope after 6 months of implementation. Conclusions: Revised silicon retinal tacks showed good performance during the operation and good biocompatibility for 6 months. Silicon retinal tacks are good fixing material for the delicate epiretinal prosthesis in situ.
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