May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
New Computer Program to Analyze OCT Images of Fovea Quantitatively Before and After Photodynamic Therapy
K. Ishikawa; H. Terasaki; Y. Ito; M. Kikuchi; H. Oshima; H. Nishihara; T. Yamakoshi; Y. Miyake
Author Affiliations & Notes
  • K. Ishikawa
    Nagoya University School of Medicine, 65 Tsuruma–cho, Showa–ku, Nagoya, Japan
  • H. Terasaki
    Nagoya University School of Medicine, 65 Tsuruma–cho, Showa–ku, Nagoya, Japan
  • Y. Ito
    Nagoya University School of Medicine, 65 Tsuruma–cho, Showa–ku, Nagoya, Japan
  • M. Kikuchi
    Nagoya University School of Medicine, 65 Tsuruma–cho, Showa–ku, Nagoya, Japan
  • H. Oshima
    Nagoya University School of Medicine, 65 Tsuruma–cho, Showa–ku, Nagoya, Japan
  • H. Nishihara
    Nagoya University School of Medicine, 65 Tsuruma–cho, Showa–ku, Nagoya, Japan
  • T. Yamakoshi
    Nagoya University School of Medicine, 65 Tsuruma–cho, Showa–ku, Nagoya, Japan
  • Y. Miyake
    Nagoya University School of Medicine, 65 Tsuruma–cho, Showa–ku, Nagoya, Japan
  • Footnotes
    Commercial Relationships  K. Ishikawa, None; H. Terasaki, None; Y. Ito, None; M. Kikuchi, None; H. Oshima, None; H. Nishihara, None; T. Yamakoshi, None; Y. Miyake, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 1550. doi:
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      K. Ishikawa, H. Terasaki, Y. Ito, M. Kikuchi, H. Oshima, H. Nishihara, T. Yamakoshi, Y. Miyake; New Computer Program to Analyze OCT Images of Fovea Quantitatively Before and After Photodynamic Therapy . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1550.

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Abstract

Abstract: : Purpose: Optical coherence tomography (OCT) can provide useful information on the effectiveness of photodynamic therapy (PDT) for choroidal neovascularizations (CNVs). However, the retinal map protocol often cannot be used because the program included with the OCT cannot distinguish the border of retinal pigment epithelium and which is asymmetrical. The purpose of this study was to determine whether a computer program we have written can analyze the OCT images for the morphological changes of the retina after PDT. Methods: Eighit eyes with age–related macular degeneration, and 3 eyes with polypoidal choroidal vasculopathy, were treated by PDT according to the report of the "Treatment of Age–Related Macular Degeneration with Photodynamic Therapy Study Group". OCT was performed before, 1, and 3 months after PDT. Six radiating scans of 6 mm length were made with the Fast Macular Thickness Map protocol. On the OCT images, the user sets cursors on the inner limiting membrane side and retinal pigment epithelium side of the retina, and another at the fovea, and the program calculates the retinal thickness (RT), a retinal volume (RV), and a retinal map using a color code. Results: The mean RT within the 3 mm diameter circle centered on the fovea was 354.0 µm before PDT, and it was decreased to 297.9 µm, and 295.4 µm 1, and 3 months after PDT, respectively. The decrease only at 1 month was statistically significant (P= 0.04; Wilcoxon signed rank test). The mean RV within the 3 mm diameter circle centered in the fovea was 2.50 mm3, 2.11 mm3, and 2.09 mm3 before, 1, and 3 months after PDT, respectively. The decrease at 1 month was statistically significant (P = 0.04). Conclusions: Our program was able to detect a decrease of retinal thickness at one month after PDT. Our software will be able to evaluate changes in the retinal thickness and volume following PDT quantitatively.

Keywords: photodynamic therapy • age-related macular degeneration • choroid: neovascularization 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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