Purchase this article with an account.
K. Ishikawa, H. Terasaki, Y. Ito, M. Kikuchi, H. Oshima, H. Nishihara, T. Yamakoshi, Y. Miyake; New Computer Program to Analyze OCT Images of Fovea Quantitatively Before and After Photodynamic Therapy . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1550.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: Optical coherence tomography (OCT) can provide useful information on the effectiveness of photodynamic therapy (PDT) for choroidal neovascularizations (CNVs). However, the retinal map protocol often cannot be used because the program included with the OCT cannot distinguish the border of retinal pigment epithelium and which is asymmetrical. The purpose of this study was to determine whether a computer program we have written can analyze the OCT images for the morphological changes of the retina after PDT. Methods: Eighit eyes with age–related macular degeneration, and 3 eyes with polypoidal choroidal vasculopathy, were treated by PDT according to the report of the "Treatment of Age–Related Macular Degeneration with Photodynamic Therapy Study Group". OCT was performed before, 1, and 3 months after PDT. Six radiating scans of 6 mm length were made with the Fast Macular Thickness Map protocol. On the OCT images, the user sets cursors on the inner limiting membrane side and retinal pigment epithelium side of the retina, and another at the fovea, and the program calculates the retinal thickness (RT), a retinal volume (RV), and a retinal map using a color code. Results: The mean RT within the 3 mm diameter circle centered on the fovea was 354.0 µm before PDT, and it was decreased to 297.9 µm, and 295.4 µm 1, and 3 months after PDT, respectively. The decrease only at 1 month was statistically significant (P= 0.04; Wilcoxon signed rank test). The mean RV within the 3 mm diameter circle centered in the fovea was 2.50 mm3, 2.11 mm3, and 2.09 mm3 before, 1, and 3 months after PDT, respectively. The decrease at 1 month was statistically significant (P = 0.04). Conclusions: Our program was able to detect a decrease of retinal thickness at one month after PDT. Our software will be able to evaluate changes in the retinal thickness and volume following PDT quantitatively.
This PDF is available to Subscribers Only