Purchase this article with an account.
D.M. Snodderly, H.C. Chung, S.M. Caldarella, E.J. Johnson; The Influence of Supplemental Lutein and Docosahexaenoic Acid on Their Serum Levels and on Macular Pigment . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1766.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: High dietary intakes of lutein and docosahexaenoic acid (DHA) and high macular pigment (MP) may be protective against age–related macular degeneration (AMD). Lutein is a main component of MP. DHA is a key fatty acid in the retina. The purpose of this study was to determine individual and combined effects of supplemental lutein (12 mg/d) and DHA (800 mg/d) on their serum levels and MP optical density (MPOD). Methods: Fifty healthy women (60–80 y) were randomly assigned to one of four supplemental groups: placebo, lutein, DHA, and lutein+DHA. Subjects consumed the supplement daily for 4 mos. Blood was collected at 0, 2 and 4 mo and analyzed for lutein and DHA. At baseline and 4 mo, MPOD was determined by heterochromatic flicker photometry at 0.4°, 1.5°, 3° and 5° temporal retinal eccentricities. The parafoveal reference was located at 7° temporal retinal eccentricity. Results: Serum levels of lutein significantly increased from baseline after 2 and 4 mo of lutein supplementation (with or without DHA). No significant changes in serum lutein were observed in the placebo and DHA groups. At 2 mo, the lutein+DHA group had significantly higher serum levels of lutein than all other groups (p <0.05). Serum levels of DHA significantly increased from baseline after 2 and 4 mo of DHA supplementation (with or without lutein) (p < 0.0001). No significant changes of serum DHA were observed for the placebo and lutein groups. In the lutein group, there was an increase in MPOD at the 3.0° (p <0.04) and 5° loci (p <0.05). In the DHA group, there was a significant increase in MPOD at the most central locus (0.4° locus, p <0.04) with no significant changes at other loci. In the combination group (lutein+DHA) there were significant increases in MPOD at the 0.4°, 1.5°, and 3°loci (p <0.04). Conclusions: Supplementation of these elderly women with lutein alone increased MPOD eccentrically whereas DHA supplementation alone resulted in central increases in MPOD. The combination of supplements had a combined effect on MPOD. DHA facilitated accumulation of lutein in the blood. These data may have implications for the use of supplemental lutein and DHA in AMD prevention.
This PDF is available to Subscribers Only