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K. Neelam, J. Nolan, O. O' Donovan, K. Au Eong, S. Beatty; Macular Pigment Levels Following Successful Macular Hole Surgery . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1777.
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Purpose: Macular pigment (MP) is composed of two hydroxycarotenoids contained within the photoreceptors and the axons of the central neurosensory retina, with peak concentrations in Henle layer. A full–thickness macular hole (FTMH) is characterised by absence of all retinal layers in an area centred at the former centre of the fovea. We report the results of a study designed to investigate macular pigment levels following successful macular hole surgery. Methods: The following details were recorded for 12 eyes of 12 patients following successful closure of a FTMH: best corrected visual acuity; macula threshold test; fixation; fundus photography; macular pigment levels using Raman spectroscopy. High resolution imaging of the retina using optical coherence tomography (OCT) was performed in 9 of the 12 study eyes. Results: Mean best–corrected visual acuity (± SD) was 0.6 ± 0.4, and improved significantly from preoperative levels. On macula threshold testing of the operated eye, a central scotoma was detectable in one eye only (8.3%). MP levels were demonstrable in 10 of the 12 study eyes following successful FTMH surgery. MP levels were higher in 3 study eyes, and lower in 7 study eyes, when compared with the fellow eye. Of the 3 eyes with greater levels of MP than its fellow eye, macular pathology was demonstrable in 2 of these. Conclusions: We have confirmed the presence of MP in the neurosensory retina of an anatomically closed FTMH in 10 of 12 study eyes, although the levels were lower than the fellow normal macula in 9 of 10 cases. This suggests a good degree of physiological recovery of photoreceptors and their axons following successful FTMH surgery.
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