May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Linking Changes in Visual Functioning According to Changes in Visual Acuity Among Patients With Age–Related Macular Degeneration
Author Affiliations & Notes
  • A.M. Pleil
    Pfizer Inc, Global Research & Development, 10777 Science Center Drive (B95), San Diego, CA
  • J.C. Cappelleri
    Pfizer Inc, Global Research & Development, Eastern Point Road, Groton, CT
  • J.R. Thompson
    Pfizer Inc, Global Research & Development, Eastern Point Road, Groton, CT
  • C.A. Getter
    Pfizer Inc, Global Research & Development, Eastern Point Road, Groton, CT
  • S.C. Li
    Pfizer Inc, Global Research & Development, Eastern Point Road, Groton, CT
  • R. Coleman
    Pfizer Inc, Global Research & Development, Eastern Point Road, Groton, CT
  • S. Chikkala
    Pfizer Inc, Global Research & Development, Eastern Point Road, Groton, CT
  • K. Knur
    Department of Ophthalmology, University Leipzig, Leipzig, Germany
  • M.B. Reichel
    Augenabteilung Klinikum Konstanz, Konstanz, Germany
  • S. Wolf
    Department of Opthalmology, University Bern, Bern, Switzerland
  • Footnotes
    Commercial Relationships  A.M. Pleil, Pfizer Inc E; J.C. Cappelleri, Pfizer Inc E; J.R. Thompson, Pfizer Inc E; C.A. Getter, None; S.C. Li, Pfizer Inc E; R. Coleman, Pfizer Inc C; S. Chikkala, Pfizer Inc., Global Research & Development C; K. Knur, Pfizer Inc F; M.B. Reichel, Pfizer Inc F; S. Wolf, Pfizer Inc F.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 1917. doi:
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      A.M. Pleil, J.C. Cappelleri, J.R. Thompson, C.A. Getter, S.C. Li, R. Coleman, S. Chikkala, K. Knur, M.B. Reichel, S. Wolf; Linking Changes in Visual Functioning According to Changes in Visual Acuity Among Patients With Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1917.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To assess the degree to which changes in visual acuity correspond to changes in self–reported visual functioning over 12 months in patients with age–related macular degeneration (AMD). Methods: Patients with varying stages of AMD were recruited for a prospective observational study. Among the examinations were ETDRS visual acuity and the German version of the 25–item National Eye Institute Visual Functioning Questionnaire (NEI–VFQ). Scores on the 12 NEI–VFQ subscales can range from 0 to 100. Higher scores corresponded with better vision–related quality of life. Lines lost on visual acuity from baseline to Month 12 in the eye with better visual acuity were bifurcated into two groups (<3 vs. ≥3 ETDRS lines lost). Within and between these two groups, mean changes from baseline to Month 12 on NEI–VFQ scores were assessed with a t test. Results: Mean (SD) age was 72.5 (7.6), and mean visual acuity in decimal form was 0.76 (0.34) in the baseline better functioning eye. Of the 171 patients with completed data, 21 patients lost 3 or more lines. Mean changes on most NEI–VFQ subscales showed more deterioration in visual functioning in the group losing 3+ lines, with tangible and statistical differences in mean changes (p<0.01) between groups of 18.7 (SD=17.5) in Near Vision, 22.6 (20.2) in Distance Vision, 18.0 (20.0) in Dependency, 29.6 (19.6) in Social Functioning, and 11.9 (10) in the Composite Score. Conclusions: A loss of visual acuity of three lines or more in the better functioning eye is linked to substantial loss of vision–related quality of life. These data support the sensitivity of the 25–item NEI–VFQ (German version) to detect a clinically meaningful 3–line loss of visual acuity in the better eye.

Keywords: age-related macular degeneration • quality of life • clinical (human) or epidemiologic studies: outcomes/complications 
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