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E. Goto, M. Dogru, Y. Matsumoto, K. Fukagawa, M. Saiki, M. Uchino, T. Kojima, Y. Yamamoto, M. Kawashima, K. Tsubota; Topical Eye Ointment Application to Lid Margin for the Treatment of Dry Eye . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2040.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To assess the efficacy of minimal–dose lipid eye ointment application to lid margin for the treatment of dry eye. Methods: Sixty two eyes of 31 consecutive dry eye patients were examined in the sub–specialty clinic in Tokyo Dry Eye Center in Iidabashi Eye Clinic. Four cases were performed LASIK surgery. Dry eye patients were firstly treated with conventional topical treatment such as artificial eye drops or steroid eye drops. In the next visit after 2 weeks, DR–1 (Kowa, Nagoya, Japan) tear interfeometry was performed and subjects with thin precorneal lipid layer were included in the present study. To supply missing lipid on the ocular surface, from commercially available topical lipid drugs, ofloxacin eye ointment (Tarivid, Santen Pharmaceutical, Co, Japan) was chosen since it spread well over the cornea to form lipid layer, and was applied to lid margin with minimal low dose 3 times a day for 2 weeks. Informed consent was obtained from all the subjects, and IRB approval was also obtained. Dry eye symptom using visual analogue scale, DR–1 tear interferometry to assess lipid layer thickness, fluorescein corneal vital staining, tear break–up time (BUT), and meibum expressibility were investigated. Results: After 2 weeks of treatment, symptom scale scores improved from 79.0 Â± 38.2 to 38.2 Â± 18.3 (P < 0.0001). Precorneal lipid layer thickness increased from 35.0 Â± 6.1 nm to 74.5 Â± 27.8 nm (P < 0.0001). BUT also improved significantly. Conclusions: Dry eye patients with thin precorneal lipid layer were successfully treated with minimal–dose ofloxacin eye ointment application to lid margin. DR–1 tear interferometry indicated smooth spread of eye ointment on the cornea and increase of lipid layer thickness after the application, accompanied with the improvement of the symptoms. This treatment was effective to the dry eye with thin surface lipid layer, and may help to suppress excessive evaporative tear loss from ocular surface leading to decreased dryness.
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