May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Histological Findings of Rabbit Cornea Produced by an Orthokeratology Lens
Author Affiliations & Notes
  • M. Matsubara
    Ophthalmology, Daini Hospital, Tokyo Womens Medical Uni, Arakawa–Ku, Japan
  • S. Takeda
    Ophthalmology, Daini Hospital, Tokyo Womens Medical Uni, Arakawa–Ku, Japan
  • T. Hirowatari
    Ophthalmology, Daini Hospital, Tokyo Womens Medical Uni, Arakawa–Ku, Japan
  • K. Mukai
    New Vision Institute, Taito–Ku, Japan
  • Y. Ishii
    New Vision Institute, Taito–Ku, Japan
  • Footnotes
    Commercial Relationships  M. Matsubara, None; S. Takeda, None; T. Hirowatari, None; K. Mukai, None; Y. Ishii, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2058. doi:https://doi.org/
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      M. Matsubara, S. Takeda, T. Hirowatari, K. Mukai, Y. Ishii; Histological Findings of Rabbit Cornea Produced by an Orthokeratology Lens . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2058. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To report the topographical epithelial changes histologically after the use of orthokeratology lens (ortho–K lens) in rabbit cornea. Methods:An ortho–K lens (target reduction; –3.0 diopter) was continuously inserted into right eyes of white rabbits. Eyes were enucleated after 4 weeks, and served to histological examination using hematoxylin–eosin staining and electron microscopic study. Left eyes were used as controls. Results:Panoramic view of cornea showed apparent topographical changes of epithelial thickness corresponding to portions of Ortho–K lens. In the area that corresponds to the base curve zone, epithelial layers showed almost normal configuration. In the reverse curve zone, epithelium was thick with 7 to 9 layers. Epithelial layers were thinnest in the alignment curve zone. Electron microscopic study revealed slightly increased proteoglycans in deep stroma at the center. Epithelial cells in any area showed no abnormal staining pattern. Conclusions: Continuous wear of Ortho–K lens gives topographical epithelial changes in thickness.

Keywords: contact lens • cornea: epithelium • pathology: experimental 
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