May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Stem Cells in the Central Cornea in Mammals
Author Affiliations & Notes
  • F. Majo
    Ophthalmology, Hôpital Jules Gonin, Lausanne, Switzerland
    Ecole Polytechnique Fédérale de Lausanne / Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
  • A. Rochat
    Ecole Polytechnique Fédérale de Lausanne / Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
  • T. Hoang–Xuan
    Ophthalmology, Hôpital Bichat Claude Bernard / Fondation A. de Rothschild, Paris, France
  • Y. Barrandon
    Ecole Polytechnique Fédérale de Lausanne / Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
  • Footnotes
    Commercial Relationships  F. Majo, None; A. Rochat, None; T. Hoang–Xuan, None; Y. Barrandon, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2087. doi:
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    • Get Citation

      F. Majo, A. Rochat, T. Hoang–Xuan, Y. Barrandon; Stem Cells in the Central Cornea in Mammals . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2087.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : The cornea is supposed to contain only transient amplifying cells (TAC) with limited growth capabilities generated by stem cells located at the limbus. Using a mouse model and a surgical approach, we have demonstrated that the corneal epithelium of the mouse self renews for months and can be serially transplanted and that the limbus does not normally contribute to corneal renewal under physiological conditions. We have also demonstrated the central cornea of several mammals contains clonogenic epithelial cells with extensive self renewal capacities. Collectively, our results demonstrate that the corneal epithelium of many mammals is self–maintained and contains stem cells. This implies that the mechanism of the renewal of the human cornea is an exception in mammals or that it should be revisited. Our results have significant implications in physiology, in pathology and for the therapeutic of ocular surface diseases.

Keywords: cornea: epithelium • cornea: basic science • transplantation 
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