May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Oxygen Depletion in Retina Artery–Vein Pairs and Optic Nerve Head (ONH) Tissues Using Hyperspectral Imaging
B. Khoobehi; H. Kawano; J.–F. Ning; F. Khan; C.F. Burgoyne; H.W. Thompson; J.M. Beach
Author Affiliations & Notes
  • B. Khoobehi
    Department of Ophthalmology, LSU Eye Center, New Orleans, LA
  • H. Kawano
    Department of Ophthalmology, LSU Eye Center, New Orleans, LA
  • J.–F. Ning
    Department of Ophthalmology, LSU Eye Center, New Orleans, LA
  • F. Khan
    Department of Ophthalmology, LSU Eye Center, New Orleans, LA
  • C.F. Burgoyne
    Department of Ophthalmology, LSU Eye Center, New Orleans, LA
  • H.W. Thompson
    Department of Ophthalmology, LSU Eye Center, New Orleans, LA
  • J.M. Beach
    Institute for Technology Development, Stennis Space Center, MS
  • Footnotes
    Commercial Relationships  B. Khoobehi, None; H. Kawano, None; J. Ning, None; F. Khan, None; C.F. Burgoyne, None; H.W. Thompson, None; J.M. Beach, None.
  • Footnotes
    Support  R03EY014872 (BK); R01EY011610 (CFB); P30EY02377 (LSU Eye Center core grant); RPB
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2375. doi:
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      B. Khoobehi, H. Kawano, J.–F. Ning, F. Khan, C.F. Burgoyne, H.W. Thompson, J.M. Beach; Oxygen Depletion in Retina Artery–Vein Pairs and Optic Nerve Head (ONH) Tissues Using Hyperspectral Imaging . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2375.

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Abstract

Abstract: : Purpose: To use a non–invasive hyperspectral imaging (HSI) method to evaluate the oxygen saturation of the ONH tissues and retinal artery–vein pairs during acute intraocular pressure elevation. Methods:Five cynomolgus monkeys with normal eyes were used. Intraocular pressure was set to 10, 30, 45, and 55 mm Hg in both eyes of each monkey and three fundus hyperspectral images were obtained after 10 minutes and three more after 30 minutes at each pressure. Three compliance tests were performed before and after the hyperspectral imaging sessions using the Heidelberg Retinal Tomograph–II to document the baseline and post–experimental condition of the ONH and vessels. Blood pressure was measured periodically throughout the procedure. The data were analyzed using a nested analysis of variance (ANOVA). Results:A comparison of the compliance test results obtained before and after the HSI experiments revealed no damage to the ONH due to acute intraocular pressure elevations. The relative saturation index (RSI) values calculated from the hyperspectral imaging data showed the following: 1) Changes in oxygen saturation within the arteries as intraocular pressure increased from 10 to 30 mm Hg were not significant. However, oxygen saturation was decreased significantly (P < 0.0001) at 45 and 55 mm Hg. 2) Significant desaturation was found within the veins at 30, 45, and 55 mm Hg , compared with 10 mm Hg (P < 0.0001). 3) ONH tissues (superior, nasal, temporal, and cup areas) showed no significant changes at intraocular pressures of 30 and 45 mmHg, compared with 10 mm Hg, although some tendency toward significance was seen in the inferior region (P = 0.0052). All regions of the ONH tissues showed significant changes at 55 mmHg (P < 0.0001). There were no differences in the results at 10 minutes and 30 minutes in any tissue at any intraocular pressure. Conclusions: The results of this study suggest the autoregulatory mechanisms that control oxygen saturation are different in the retinal vessels and ONH tissues.

Keywords: intraocular pressure • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic disc 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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