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J.J. Wang, A. Lee, E.–M. Chia, E. Rochtchina, W. Smith, R.G. Cumming, P. Mitchell, Blue Mountains Eye Study; 10–Year Incidence of Early and Late Age–Related Maculopathy: The Blue Mountains Eye Study . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2376.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To assess the 10–year incidence of age–related maculopathy (ARM) in an older Australian cohort. Methods: Of the 3654 Blue Mountains Eye Study participants aged 49+ years examined during 1992–4, 2335 (75% of survivors) were re–examined at 5–year (1997–9) and 1935 (75.0% of survivors) at 10–year (2002–4) exams. The same graders performed retinal grading in all exams, using the Wisconsin ARM Grading System. Photographs of participants with ARM lesions at any of the exams were subsequently re–graded using a side–by–side comparison method. Incident late ARM was defined if either two late lesions developed in persons free of these lesions in both eyes at baseline. Incident early ARM was defined if early ARM developed in persons free of early and late ARM at baseline. ARM incidence was calculated firstly among participants who were seen at the 10–year follow up exams (regardless of whether they attended 5–year exams). Analyses were repeated among participants seen at either the 5– or 10–year exams (780 participants were seen at the 5–year but not 10–year exams). Results: After excluding 1073 persons who died during the 10–year period, 1935 of 2581 (75.0 %) surviving baseline participants were re–examined at the 10–year follow up. Of these, 1559 with gradable retinal photographs were considered at risk. Incident late ARM was detected in 39 persons (2.5%). Women (2.8%) had a slightly higher late ARM incidence than men (1.7%), but this difference was not significant after adjusting for age (OR1.9, CI 0.9–3.6). Incident early ARM was detected in 210/ 1444 participants (14.5%) at risk for early ARM. No apparent gender difference was evident (15.2% in women and 13.6% in men, age adjusted OR 1.1, CI 0.8–1.5). Similar incidence rates were found after including participants seen at the 5–year but not at the 10–year exams (2.4% for late and 13.5% for late ARM). After age–standardizing our population to the Beaver Dam Eye Study 10–year population, the 10–year incidence of late and early ARM in this Australian population was 2.6 % and 12.8 %, respectively. Age was strongly associated with both incident late and early ARM (p for trend <0.0001). Conclusions: The age–standardized 10–year incidence rates for late and early ARM in persons aged 49 years or older in our study (2.6%, 12.8%) are very close to those reported by the Beaver Dam Eye Study (2.1%, 12.1%).
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