May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
10–Year Incidence of Early and Late Age–Related Maculopathy: The Blue Mountains Eye Study
J.J. Wang; A. Lee; E.–M. Chia; E. Rochtchina; W. Smith; R.G. Cumming; P. Mitchell; Blue Mountains Eye Study
Author Affiliations & Notes
  • J.J. Wang
    Ophthalmology (Centre for Vision Research), University of Sydney, Westmead Hospital, Sydney, Australia
  • A. Lee
    Ophthalmology (Centre for Vision Research), University of Sydney, Westmead Hospital, Sydney, Australia
  • E.–M. Chia
    Ophthalmology (Centre for Vision Research), University of Sydney, Westmead Hospital, Sydney, Australia
  • E. Rochtchina
    Ophthalmology (Centre for Vision Research), University of Sydney, Westmead Hospital, Sydney, Australia
  • W. Smith
    Centre for Clinical Epidemiology and Biostatistics/University of Newcastle, Newcastle, Australia
  • R.G. Cumming
    Public Health, University of Sydney, Sydney, Australia
  • P. Mitchell
    Ophthalmology (Centre for Vision Research), University of Sydney, Westmead Hospital, Sydney, Australia
  • Blue Mountains Eye Study
    Ophthalmology (Centre for Vision Research), University of Sydney, Westmead Hospital, Sydney, Australia
  • Footnotes
    Commercial Relationships  J.J. Wang, None; A. Lee, None; E. Chia, None; E. Rochtchina, None; W. Smith, None; R.G. Cumming, None; P. Mitchell, None.
  • Footnotes
    Support  Australian NHMRC Grant No. 211069
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2376. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      10–Year Incidence of Early and Late Age–Related Maculopathy: The Blue Mountains Eye Study
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      J.J. Wang, A. Lee, E.–M. Chia, E. Rochtchina, W. Smith, R.G. Cumming, P. Mitchell, Blue Mountains Eye Study; 10–Year Incidence of Early and Late Age–Related Maculopathy: The Blue Mountains Eye Study . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2376.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Abstract: : Purpose:To assess the 10–year incidence of age–related maculopathy (ARM) in an older Australian cohort. Methods: Of the 3654 Blue Mountains Eye Study participants aged 49+ years examined during 1992–4, 2335 (75% of survivors) were re–examined at 5–year (1997–9) and 1935 (75.0% of survivors) at 10–year (2002–4) exams. The same graders performed retinal grading in all exams, using the Wisconsin ARM Grading System. Photographs of participants with ARM lesions at any of the exams were subsequently re–graded using a side–by–side comparison method. Incident late ARM was defined if either two late lesions developed in persons free of these lesions in both eyes at baseline. Incident early ARM was defined if early ARM developed in persons free of early and late ARM at baseline. ARM incidence was calculated firstly among participants who were seen at the 10–year follow up exams (regardless of whether they attended 5–year exams). Analyses were repeated among participants seen at either the 5– or 10–year exams (780 participants were seen at the 5–year but not 10–year exams). Results: After excluding 1073 persons who died during the 10–year period, 1935 of 2581 (75.0 %) surviving baseline participants were re–examined at the 10–year follow up. Of these, 1559 with gradable retinal photographs were considered at risk. Incident late ARM was detected in 39 persons (2.5%). Women (2.8%) had a slightly higher late ARM incidence than men (1.7%), but this difference was not significant after adjusting for age (OR1.9, CI 0.9–3.6). Incident early ARM was detected in 210/ 1444 participants (14.5%) at risk for early ARM. No apparent gender difference was evident (15.2% in women and 13.6% in men, age adjusted OR 1.1, CI 0.8–1.5). Similar incidence rates were found after including participants seen at the 5–year but not at the 10–year exams (2.4% for late and 13.5% for late ARM). After age–standardizing our population to the Beaver Dam Eye Study 10–year population, the 10–year incidence of late and early ARM in this Australian population was 2.6 % and 12.8 %, respectively. Age was strongly associated with both incident late and early ARM (p for trend <0.0001). Conclusions: The age–standardized 10–year incidence rates for late and early ARM in persons aged 49 years or older in our study (2.6%, 12.8%) are very close to those reported by the Beaver Dam Eye Study (2.1%, 12.1%).

Keywords: age-related macular degeneration • clinical (human) or epidemiologic studies: prevalence/incidence 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept