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J.W. Kiel; Effects of Alpha Adrenergic Blockade on Aqueous Flow, Ciliary Blood Flow and Orbital Venous Pressure . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2411.
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To assess the effects of systemic, non–selective alpha adrenergic blockade with phentolamine on ocular hydrodynamics. This study used pentobarbital anesthetized rabbits in which mean arterial pressure (MAP) and intraocular pressure (IOP) were measured by direct cannulation. In Group 1 (n=7), aqueous flow was measured by fluorophotometry. In Group 2 (n=11), ciliary blood flow was measured by laser Doppler flowmetry (LDF). In some animals (n=7), the facial vein was cannulated to measure cranial venous pressure (Pv); in others, choroidal blood flow was measured by LDF (n=3). Measurements were made before and after administration of phentolamine (0.1 mg/kg, iv).
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