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S. Piermarocchi, E. Midena, S. Vujosevic, M. Sartore, G. Monterosso, E. Pilotto; Autofluorescence and Retinal Sensitivity in Exudative Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2429.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Retinal autofluorescence (AF) reflects the amount of lipofuscin in the retinal pigment epithelium (RPE) which increases with age. AF is particularly evident in retinal areas adjacent to chorio–retinal atrophy and over newly–formed choroidal neovascularization (CNV) during age–related macular degeneration (AMD). The aim of this study was to analyze the relationship between AF and retinal sensitivity in patients with exudative AMD. Methods: Thirty–nine with AMD and occult CNV have been recruited and studied for 488 nm AF (HRA II, Heidelberg Eng., Germany), retinal sensitivity and fixation stability with microperimetry (MP1, Nidek Co, Japan). Fluo and ICG angiography and an OCT retinal thickness analysis were also done. Results: Mean retinal sensitivity, fixation stability and BCVA show significantly high positive correlation with AF, whilst angiographically active CNV are associated to increased retinal thickness, reduced or absent AF, and more altered psycophysical tests. Conclusions: Retinal AF reflects progressive aging of RPE but may also provide crucial information as to the viability of this cellular layer. RPE is involved in the equilibrium which controls growth of CNV in AMD. This study has demonstrated that AF is associated to less active CNV and better functioning photoreceptors as indicated by microperimetry. AF may represent a simple method to predict visual prognosis in patients with AMD complicated by occult CNV.
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