May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Effects of Topical Indomethacin in Patients With Open Angle Glaucoma on Bimatoprost 0,03%
Author Affiliations & Notes
  • A. Paranhos
    Depto de Oftalmologia, Federal University of Sao Paulo, Sao Paulo, Brazil
  • F. Spadaro
    Depto de Oftalmologia, Federal University of Goias, Goiania, Brazil
  • C.M. Queiroz
    Depto de Oftalmologia, Federal University of Goias, Goiania, Brazil
  • A.P. G. Sagawa
    Depto de Oftalmologia, Federal University of Goias, Goiania, Brazil
  • M.P. Avila
    Depto de Oftalmologia, Federal University of Goias, Goiania, Brazil
  • Footnotes
    Commercial Relationships  A. Paranhos, None; F. Spadaro, None; C.M. Queiroz, None; A.P.G. Sagawa, None; M.P. Avila, None.
  • Footnotes
    Support  AP
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2463. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      A. Paranhos, F. Spadaro, C.M. Queiroz, A.P. G. Sagawa, M.P. Avila; Effects of Topical Indomethacin in Patients With Open Angle Glaucoma on Bimatoprost 0,03% . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2463.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Abstract:
 

To investigate the effects of a topical inhibitor ofprostaglandin (indomethacin) on hypotensive effect of Bimatoprost(LumiganTM), and its influence in hyperemia and visual field.

 

Randomized double masked clinical trial. Twenty eightadults volunteers patients with open angle glaucoma were randomlydivided into two groups: group A Indometacin (n=13) or groupB placebo (n=15). It was evaluated the hypotensive effect, conjuctivalhyperemia, after fifteen days , one month and monthly untilsixth month follow–up. Visual fields were evaluated afterbefore and after 6 months.

 

The mean age was 59,5 anos group A and 51,3 years forgroup B. There was no statistic difference in age (p=0,11).The baseline intraocular pressure was 21,3+/– 6,5 ( mean+/–SD) for group A and 21,9+/–4,6 for group B. There wereno statistically significant differences between both groupin all periods for IOP (table I) (p=0,31). Hyperemia until threemonths was minor in group A after this period was equal forboth groups (p>0,05) (table II). There were no statisticallysignificant difference regarding visual field MD after 6 monthsbetween the two groups (p=0.96).

 

 

  Blocking endogenous prostaglanding with topicalindometacin did not affect the IOP lowering effect of bimatoprostor its collateral effects as also visual field changes over6 months period.

 

 
Keywords: intraocular pressure • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled • drug toxicity/drug effects 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×