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A. Paranhos, F. Spadaro, C.M. Queiroz, A.P. G. Sagawa, M.P. Avila; Effects of Topical Indomethacin in Patients With Open Angle Glaucoma on Bimatoprost 0,03% . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2463.
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To investigate the effects of a topical inhibitor ofprostaglandin (indomethacin) on hypotensive effect of Bimatoprost(LumiganTM), and its influence in hyperemia and visual field.
Randomized double masked clinical trial. Twenty eightadults volunteers patients with open angle glaucoma were randomlydivided into two groups: group A Indometacin (n=13) or groupB placebo (n=15). It was evaluated the hypotensive effect, conjuctivalhyperemia, after fifteen days , one month and monthly untilsixth month follow–up. Visual fields were evaluated afterbefore and after 6 months.
The mean age was 59,5 anos group A and 51,3 years forgroup B. There was no statistic difference in age (p=0,11).The baseline intraocular pressure was 21,3+/– 6,5 ( mean+/–SD) for group A and 21,9+/–4,6 for group B. There wereno statistically significant differences between both groupin all periods for IOP (table I) (p=0,31). Hyperemia until threemonths was minor in group A after this period was equal forboth groups (p>0,05) (table II). There were no statisticallysignificant difference regarding visual field MD after 6 monthsbetween the two groups (p=0.96).
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